Clinical and Technical Requirements for Proton Treatment Planning of Ocular Diseases

Chauvel, P; Sauerwein, W.; Bornfeld, Norbert; Friedrichs, Wilko; Brassart, Nicolas; Courdi, A.; Hérault, J.; Pignol, J.; Bondiau, Pierre‐Yves; Malandain, Grégoire

doi:10.1159/000425696

Cited by 14 publications

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“…These potential reasons for poor modeling include discrepancies in ͑1͒ the eye length as seen on ultrasound; ͑2͒ surgical measurements of the clips; ͑3͒ shape of the eye, which can be irregular and may need important approximations in the eye model; ͑4͒ the uncertainty in the range because of the estimate of the eye density; and ͑5͒ improper initial fixation at time of simulation. For example, the EYEPLAN software uses a spherical model of the eye and in some patients, the eye may not be spherical ͑due to myopia or hyperopia͒ as argued by Chauvel et al, 20 where the uncertainties may be compensated by larger safety margins. Dobler et al 21 have developed a new 3D treatment planning system OCTOPUS for proton therapy of ocular tumors, which takes account of precise modeling of the patient's anatomy, thus reducing the planning uncertainties.…”

Section: Introductionmentioning

confidence: 99%

Fundus image fusion in EYEPLAN software: An evaluation of a novel technique for ocular melanoma radiation treatment planning

et al. 2010

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Purpose:The purpose of this study is to evaluate a novel approach for treatment planning using digital fundus image fusion in EYEPLAN for proton beam radiation therapy ͑PBRT͒ planning for ocular melanoma. The authors used a prototype version of EYEPLAN software, which allows for digital registration of high-resolution fundus photographs. The authors examined the improvement in tumor localization by replanning with the addition of fundus photo superimposition in patients with macular area tumors. Methods:The new version of EYEPLAN ͑v3.05͒ software allows for the registration of fundus photographs as a background image. This is then used in conjunction with clinical examination, tantalum marker clips, surgeon's mapping, and ultrasound to draw the tumor contour accurately. In order to determine if the fundus image superimposition helps in tumor delineation and treatment planning, the authors identified 79 patients with choroidal melanoma in the macular location that were treated with PBRT. All patients were treated to a dose of 56 GyE in four fractions. The authors reviewed and replanned all 79 macular melanoma cases with superimposition of pretreatment and post-treatment fundus imaging in the new EYEPLAN software. For patients with no local failure, the authors analyzed whether fundus photograph fusion accurately depicted and confirmed tumor volumes as outlined in the original treatment plan. For patients with local failure, the authors determined whether the addition of the fundus photograph might have benefited in terms of more accurate tumor volume delineation. Results: The mean follow-up of patients was 33.6Ϯ 23 months. Tumor growth was seen in six eyes of the 79 macular lesions. All six patients were marginal failures or tumor miss in the region of dose fall-off, including one patient with both in-field recurrence as well as marginal. Among the six recurrences, three were managed by enucleation and one underwent retreatment with proton therapy. Three patients developed distant metastasis and all three patients have since died. The replanning of six patients with their original fundus photograph superimposed showed that in four cases, the treatment field adequately covered the tumor volume. In the other two patients, the overlaid fundus photographs indicated the area of marginal miss. The replanning with the fundus photograph showed improved tumor coverage in these two macular lesions. For the remaining patients without local failure, replanning with fundus photograph superimposition confirmed the tumor volume as drawn in the original treatment plan. Conclusions: Local control was excellent in patients receiving 56 GyE of PBRT for uveal melanomas in the macular region, which traditionally can be more difficult to control. Posterior lesions are better defined with the additional use of fundus image since they can be difficult to mark surgically. In one-third of treatment failing patients, the superposition of the fundus photograph would have clearly allowed improved localization of tumor. The current practice s...

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Section: Introductionmentioning

confidence: 99%

Fundus image fusion in EYEPLAN software: An evaluation of a novel technique for ocular melanoma radiation treatment planning

et al. 2010

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“…Proton beam therapy is a standard of care for treatment of uveal melanoma and is quite effective in achieving excellent local control rates reported at 95% or higher by numerous authors . For continuing this high rate of success, accurate and reproducible tools are necessary in the planning process.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, measurement of the globe with ultrasound is not possible if silicone has been introduced in the globe. Chauvel et al . argued that these uncertainties might be compensated by larger safety margins.…”

Section: Introductionmentioning

confidence: 99%

Technical Note: Feasibility study of titanium markers in choroidal melanoma localization for proton beam radiation therapy

et al. 2018

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“…Thus, we investigated the fusion between those images and 3D MR images where the clip detection could be possible [7,8].…”

Section: The Clipsmentioning

confidence: 99%

Eye reconstruction and CT-retinography fusion for proton treatment planning of ocular diseases

Bondiau

Malandain

1997

Lecture Notes in Computer Science

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We present here a technique for reconstructing an eye, to guide the protontherapy of ocular tumours. This approach is expected to considerably improve the safety of the therapy. Our method is twofold. First, we present the eye's reconstruction from scanner images. Second, we describe the retinography and demonstrate the projection equations of this modality. This last result allows us to combine retinography with the reconstructed eye to get a virtual eye.

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Clinical and Technical Requirements for Proton Treatment Planning of Ocular Diseases

Cited by 14 publications

References 0 publications

Fundus image fusion in EYEPLAN software: An evaluation of a novel technique for ocular melanoma radiation treatment planning

Fundus image fusion in EYEPLAN software: An evaluation of a novel technique for ocular melanoma radiation treatment planning

Technical Note: Feasibility study of titanium markers in choroidal melanoma localization for proton beam radiation therapy

Eye reconstruction and CT-retinography fusion for proton treatment planning of ocular diseases

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