Clinical and Radiological Long-term Outcomes After Matrix-Induced Autologous Chondrocyte Transplantation

Aldrian, Silke; Žák, Lukáš; Wondrasch, Barbara; Albrecht, Christian; Stelzeneder, Beate; Binder, Harald; Kovar, Florian M.; Trattnig, Siegfried; Marlovits, Stefan

doi:10.1177/0363546514548160

Cited by 92 publications

(121 citation statements)

References 43 publications

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“…The average postoperative follow-up time was 11.4 years (range, 9.2-18 years). Seven studies had a minimum followup greater than 9 years [14][15][16][17]29,34,35 , while 2 studies included patients with minimum follow-ups of 6 and 7 years. 33,43 The mean defect size was 5.9 ± 1.6 cm 2 (range, 0.6-15.8 cm 2 ).…”

Section: Patient Characteristicsmentioning

confidence: 99%

Long-Term Outcomes after Autologous Chondrocyte Implantation

et al. 2016

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Section: Patient Characteristicsmentioning

confidence: 99%

Long-Term Outcomes after Autologous Chondrocyte Implantation

et al. 2016

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“…The first long-term data, 10 years after MACT for treatment of chondral defects, show significantly improved clinical and radiological outcome measures in patients with symptomatic traumatic cartilage lesions. 73 The use of scaffolds in a threedimensional culture system helps to optimize chondrocyte transplantation from not only a biological but also from a surgical point of view. However, delamination or disturbed fusion to the surrounding native cartilage and subchondral bone are still problems for the third-generation ACI.…”

Section: Developments In Acimentioning

confidence: 99%

Autologous chondrocyte implantation for cartilage repair: current perspectives

Zellner¹,

Krutsch²,

Pfeifer³

et al. 2015

ORR

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Over the last decade, regenerative treatment options have become the more routinely used techniques for treatment of cartilage defects, with predictable outcomes for their specific indications. For large chondral lesions in young patients, in particular, autologous chondrocyte implantation is the treatment of choice for restoration of joint health. This review focuses on indications, results, and outcome predictors of autologous chondrocyte implantation in comparison to other regenerative treatment procedures and discusses improvement options and future perspectives for autologous chondrocyte transplantation. As research activities are increasing in the field of regenerative joint therapy, recent developments may help to overcome remaining limitations step by step.

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“…In limited cartilage defects autologous chondrocyte implantation has been clinically applied for several years already. In contrast, the translation of anatomically shaped constructs for functional joint repair is still difficult to achieve11121314. Recent pioneering work has demonstrated the successful construction of customized anatomically shaped cartilage using human adipose-derived stem cells for total joint resurfacing15.…”

mentioning

confidence: 99%

Autologous temporomandibular joint reconstruction independent of exogenous additives: a proof-of-concept study for guided self-generation

Wei

Herrler

Han

et al. 2016

Sci Rep

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Joint defects are complex and difficult to reconstruct. By exploiting the body’s own regenerative capacity, we aimed to individually generate anatomically precise neo-tissue constructs for autologous joint reconstruction without using any exogenous additives. In a goat model, CT scans of the mandibular condyle including articular surface and a large portion of the ascending ramus were processed using computer-aided design and manufacturing. A corresponding hydroxylapatite negative mold was printed in 3D and temporarily embedded into the transition zone of costal periosteum and perichondrium. A demineralized bone matrix scaffold implanted on the contralateral side served as control. Neo-tissue constructs obtained by guided self-generation exhibited accurate configuration, robust vascularization, biomechanical stability, and function. After autologous replacement surgery, the constructs showed stable results with similar anatomical, histological, and functional findings compared to native controls. Further studies are required to assess long-term outcome and possible extensions to other further applications. The absence of exogenous cells, growth factors, and scaffolds may facilitate clinical translation of this approach.

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Clinical and Radiological Long-term Outcomes After Matrix-Induced Autologous Chondrocyte Transplantation

Abstract: The significantly improved results on 3 outcome measures after 10 years suggest that MACT represents a suitable option in the treatment of local cartilage defects in the knee.

Cited by 92 publications

References 43 publications

Long-Term Outcomes after Autologous Chondrocyte Implantation

Long-Term Outcomes after Autologous Chondrocyte Implantation

Autologous chondrocyte implantation for cartilage repair: current perspectives

Autologous temporomandibular joint reconstruction independent of exogenous additives: a proof-of-concept study for guided self-generation

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