2005
DOI: 10.1007/s00280-005-0084-6 View full text |Buy / Rent full text
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Abstract: Co-administration of 9NC with food reduces the oral absorption of 9NC; however, there was no difference in the exposure of 9AC. The is high interpatient variability in the effect of food on the absorption of 9NC and the interpatient variability in the effect of food on the disposition of 9AC is even greater when compared to 9NC.

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“…The high AUC for 9-NC in cohort 2 may be explained by the considerable variation (up to 10-fold) in the plasma concentrations of 9-NC between patients in the same cohort and the limited number of patients per cohort. This notable variation in 9-NC plasma concentration has also been observed by others (33,34).…”
Section: Discussionsupporting
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“…The high AUC for 9-NC in cohort 2 may be explained by the considerable variation (up to 10-fold) in the plasma concentrations of 9-NC between patients in the same cohort and the limited number of patients per cohort. This notable variation in 9-NC plasma concentration has also been observed by others (33,34).…”
Section: Discussionsupporting
“…The mean AUC for 9-NC with food were 330 F 182 ng h/mL. Values for fasting patients were 558 F 379 ng h/mL (33). The high AUC for 9-NC in cohort 2 may be explained by the considerable variation (up to 10-fold) in the plasma concentrations of 9-NC between patients in the same cohort and the limited number of patients per cohort.…”
Section: Discussionmentioning
“…Polyglutamic acid (PGA)-paclitaxel copolymer (CT-2103) (Xyotax) is entering the market as cancer treatment for non-small-cell lung cancer in women (Singer 2005). Polyethyleneglycol in conjugation with camptothecin (EZ-246, Pegamotecan) (Posey et al 2005) and cyclodextrin in conjugation with camptothecin (Schluep et al 2006a, b;Zamboni et al 2006) are entering clinical trials. Polymer-drug conjugates are being directed not only against tumour cells, but also against angiogenic blood vessels, for example, HPMA-fumagillol (TNP-470) caplostatin (Satchi-Fainaro et al 2004;Huang et al 2004;Inoue et al 2003;Bhujwalla et al 2003), the HPMA copolymer-RGD4C-Tc-99m conjugate, capable of targeting tumour angiogenic vessels and delivering adequate radiotherapy to arrest tumour growth (Mitra et al 2006) and PEGylated cyclic arginine-glycine-aspartic acid (RGD) radiotracers (64-Cu-DOTAPEG-RGD and 125 I-RGD-mPEG) targeted at integrins (Chen et al 2004a, b).…”
Section: Polymersmentioning
“…The LLQ for 9AC lactone and total was 0.3 ng/mL, and the assays were linear from 0.3 ng/mL to 100 ng/mL. 9NC and 9AC total plasma concentrations from the single-dose pharmacokinetic study were simultaneously and directly quantitated using a highly sensitive and specific HPLC-tandem mass spectrometric assay that we developed [31]. Chromatography was performed on a Waters Alliance 2695 system (Milford, MA, USA) and a Luna C 18 (5 µm, 150 × 2 mm) analytical column (Phenomenex, Torrance, CA).…”
Section: Analytical Assaysmentioning