Clinical and Pathological Study of Choroidal Lipid Globules

Quantitative multimodal imaging of extensive macular atrophy with pseudodrusen and geographic atrophy with diffuse trickling pattern

“…However, on OCT scans choroidal caverns show a typical hypertransmission tail, an artifact known to be caused by lipid structures, such as the subretinal lipid globules described by Fernández-Avellaneda P. et al in patients affected by neovascular AMD 33 . This finding is consistent with a recent study conducted by Dolz-Marco R. et al, who aimed to verify the correspondence of such choroidal caverns with the lipid globules first described by Friedman E. et al in 1966 24 , 34 . Since they also found caverns in healthy patients, the authors hypothesized that they represent a normal aspect of the chorioretinal physiology, and that their persistence may reflect a slowdown in the photoreceptor metabolism 24 , 34 .…”

“…This finding is consistent with a recent study conducted by Dolz-Marco R. et al, who aimed to verify the correspondence of such choroidal caverns with the lipid globules first described by Friedman E. et al in 1966 24 , 34 . Since they also found caverns in healthy patients, the authors hypothesized that they represent a normal aspect of the chorioretinal physiology, and that their persistence may reflect a slowdown in the photoreceptor metabolism 24 , 34 . A more rapid decrease of the functional request may explain why we were able to identify choroidal caverns only in DTGA and EMAP patients.…”

Quantitative multimodal imaging of extensive macular atrophy with pseudodrusen and geographic atrophy with diffuse trickling pattern

“…However, on OCT scans choroidal caverns show a typical hypertransmission tail, an artifact known to be caused by lipid structures, such as the subretinal lipid globules described by Fernández-Avellaneda P. et al in patients affected by neovascular AMD 33 . This finding is consistent with a recent study conducted by Dolz-Marco R. et al, who aimed to verify the correspondence of such choroidal caverns with the lipid globules first described by Friedman E. et al in 1966 24 , 34 . Since they also found caverns in healthy patients, the authors hypothesized that they represent a normal aspect of the chorioretinal physiology, and that their persistence may reflect a slowdown in the photoreceptor metabolism 24 , 34 .…”

“…This finding is consistent with a recent study conducted by Dolz-Marco R. et al, who aimed to verify the correspondence of such choroidal caverns with the lipid globules first described by Friedman E. et al in 1966 24 , 34 . Since they also found caverns in healthy patients, the authors hypothesized that they represent a normal aspect of the chorioretinal physiology, and that their persistence may reflect a slowdown in the photoreceptor metabolism 24 , 34 . A more rapid decrease of the functional request may explain why we were able to identify choroidal caverns only in DTGA and EMAP patients.…”

Cavitary Choroidal Nevus Showing Thickness Fluctuations in Response to Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema: A Case Report

“…The authors postulated that these cavities could arise from the accumulation of lipids forming choroidal lipid globules, a common histologic finding in postmortem eyes which, when seen with clinical imaging, have been termed "choroidal caverns." 12,13 Our findings on multimodal imaging are consistent with these descriptions and were helpful to rule out other differential diagnoses, including choroidal hemangioma, melanoma, or metastasis.…”

“…Spontaneous increase in the cavitary component of choroidal nevi has been previously documented using OCT. 3 Corvi et al 1 recently reported a patient with bilateral pachychoroid disease and choroidal vascular permeability, presenting with hyporeflective avascular caverns within a choroidal nevus, as seen on OCT and OCTA. The authors postulated that these cavities could arise from the accumulation of lipids forming choroidal lipid globules, a common histologic finding in postmortem eyes which, when seen with clinical imaging, have been termed “choroidal caverns.” 12,13 Our findings on multimodal imaging are consistent with these descriptions and were helpful to rule out other differential diagnoses, including choroidal hemangioma, melanoma, or metastasis.…”

Hypertransmission and Vision in Aging and Age-Related Macular Degeneration: Longitudinal Data From ALSTAR2

“…Lipid globules can lead to HT tails in the choroid and sclera. 34 , 35 These histologically confirmed extracellular deposits of non-polar lipids form circular hyporeflective areas in the choroid ( Figure 3G , H , I ) or sclera. The HT tail is attributed to the lesser absorption of light through lipid than through the surrounding tissue.…”

Quantitative multimodal imaging of extensive macular atrophy with pseudodrusen and geographic atrophy with diffuse trickling pattern

“…However, on OCT scans choroidal caverns show a typical hypertransmission tail, an artifact known to be caused by lipid structures, such as the subretinal lipid globules described by Fernández-Avellaneda P. et al in patients affected by neovascular AMD 33 . This finding is consistent with a recent study conducted by Dolz-Marco R. et al, who aimed to verify the correspondence of such choroidal caverns with the lipid globules first described by Friedman E. et al in 1966 24 , 34 . Since they also found caverns in healthy patients, the authors hypothesized that they represent a normal aspect of the chorioretinal physiology, and that their persistence may reflect a slowdown in the photoreceptor metabolism 24 , 34 .…”

“…This finding is consistent with a recent study conducted by Dolz-Marco R. et al, who aimed to verify the correspondence of such choroidal caverns with the lipid globules first described by Friedman E. et al in 1966 24 , 34 . Since they also found caverns in healthy patients, the authors hypothesized that they represent a normal aspect of the chorioretinal physiology, and that their persistence may reflect a slowdown in the photoreceptor metabolism 24 , 34 . A more rapid decrease of the functional request may explain why we were able to identify choroidal caverns only in DTGA and EMAP patients.…”

Cavitary Choroidal Nevus Showing Thickness Fluctuations in Response to Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema: A Case Report

“…The authors postulated that these cavities could arise from the accumulation of lipids forming choroidal lipid globules, a common histologic finding in postmortem eyes which, when seen with clinical imaging, have been termed "choroidal caverns." 12,13 Our findings on multimodal imaging are consistent with these descriptions and were helpful to rule out other differential diagnoses, including choroidal hemangioma, melanoma, or metastasis.…”

“…Spontaneous increase in the cavitary component of choroidal nevi has been previously documented using OCT. 3 Corvi et al 1 recently reported a patient with bilateral pachychoroid disease and choroidal vascular permeability, presenting with hyporeflective avascular caverns within a choroidal nevus, as seen on OCT and OCTA. The authors postulated that these cavities could arise from the accumulation of lipids forming choroidal lipid globules, a common histologic finding in postmortem eyes which, when seen with clinical imaging, have been termed “choroidal caverns.” 12,13 Our findings on multimodal imaging are consistent with these descriptions and were helpful to rule out other differential diagnoses, including choroidal hemangioma, melanoma, or metastasis.…”

Hypertransmission and Vision in Aging and Age-Related Macular Degeneration: Longitudinal Data From ALSTAR2

“…Lipid globules can lead to HT tails in the choroid and sclera. 34 , 35 These histologically confirmed extracellular deposits of non-polar lipids form circular hyporeflective areas in the choroid ( Figure 3G , H , I ) or sclera. The HT tail is attributed to the lesser absorption of light through lipid than through the surrounding tissue.…”

Quantitative multimodal imaging of extensive macular atrophy with pseudodrusen and geographic atrophy with diffuse trickling pattern

“…However, on OCT scans choroidal caverns show a typical hypertransmission tail, an artifact known to be caused by lipid structures, such as the subretinal lipid globules described by Fernández-Avellaneda P. et al in patients affected by neovascular AMD 33 . This finding is consistent with a recent study conducted by Dolz-Marco R. et al, who aimed to verify the correspondence of such choroidal caverns with the lipid globules first described by Friedman E. et al in 1966 24 , 34 . Since they also found caverns in healthy patients, the authors hypothesized that they represent a normal aspect of the chorioretinal physiology, and that their persistence may reflect a slowdown in the photoreceptor metabolism 24 , 34 .…”

“…This finding is consistent with a recent study conducted by Dolz-Marco R. et al, who aimed to verify the correspondence of such choroidal caverns with the lipid globules first described by Friedman E. et al in 1966 24 , 34 . Since they also found caverns in healthy patients, the authors hypothesized that they represent a normal aspect of the chorioretinal physiology, and that their persistence may reflect a slowdown in the photoreceptor metabolism 24 , 34 . A more rapid decrease of the functional request may explain why we were able to identify choroidal caverns only in DTGA and EMAP patients.…”

Cavitary Choroidal Nevus Showing Thickness Fluctuations in Response to Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema: A Case Report

“…The authors postulated that these cavities could arise from the accumulation of lipids forming choroidal lipid globules, a common histologic finding in postmortem eyes which, when seen with clinical imaging, have been termed "choroidal caverns." 12,13 Our findings on multimodal imaging are consistent with these descriptions and were helpful to rule out other differential diagnoses, including choroidal hemangioma, melanoma, or metastasis.…”

“…Spontaneous increase in the cavitary component of choroidal nevi has been previously documented using OCT. 3 Corvi et al 1 recently reported a patient with bilateral pachychoroid disease and choroidal vascular permeability, presenting with hyporeflective avascular caverns within a choroidal nevus, as seen on OCT and OCTA. The authors postulated that these cavities could arise from the accumulation of lipids forming choroidal lipid globules, a common histologic finding in postmortem eyes which, when seen with clinical imaging, have been termed “choroidal caverns.” 12,13 Our findings on multimodal imaging are consistent with these descriptions and were helpful to rule out other differential diagnoses, including choroidal hemangioma, melanoma, or metastasis.…”

Hypertransmission and Vision in Aging and Age-Related Macular Degeneration: Longitudinal Data From ALSTAR2

“…Lipid globules can lead to HT tails in the choroid and sclera. 34 , 35 These histologically confirmed extracellular deposits of non-polar lipids form circular hyporeflective areas in the choroid ( Figure 3G , H , I ) or sclera. The HT tail is attributed to the lesser absorption of light through lipid than through the surrounding tissue.…”