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citations
Cited by 55 publications
(121 citation statements)
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References 28 publications
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“…1,2,[23][24][25] Consistent with our ndings, a 2019 Brazilian investigation assessing children with cerebral palsy and probable CZS, of whom 97.5% had microcephaly, using the Bayley Scale of Infant and Toddler Development III (Bayley-III) reported scores below 70 (i.e., suggesting severe developmental delays) for almost all participants across all three scales: cognitive, 95.1%; language, 97.6%; motor, 97.6%. 23 A case series study assessing 24 children with ZIKV-related microcephaly in Northeast Brazil using the Denver Developmental Screening Test II also found a high degree of impairment for neuropsychomotor development. The study reported that children with a mean age of 19.9 months scored, on average, development milestones equivalent of ages 2.1 to 3.4 months, across the domains of language, motor, and personal/social skills.…”
Section: Discussionsupporting
confidence: 83%
“…1,2,[23][24][25] Consistent with our ndings, a 2019 Brazilian investigation assessing children with cerebral palsy and probable CZS, of whom 97.5% had microcephaly, using the Bayley Scale of Infant and Toddler Development III (Bayley-III) reported scores below 70 (i.e., suggesting severe developmental delays) for almost all participants across all three scales: cognitive, 95.1%; language, 97.6%; motor, 97.6%. 23 A case series study assessing 24 children with ZIKV-related microcephaly in Northeast Brazil using the Denver Developmental Screening Test II also found a high degree of impairment for neuropsychomotor development. The study reported that children with a mean age of 19.9 months scored, on average, development milestones equivalent of ages 2.1 to 3.4 months, across the domains of language, motor, and personal/social skills.…”
Section: Discussionsupporting
confidence: 83%
“…putamen and caudate) on MRI, as well as calcification on neuropathology. Calcification in subcortical areas have been reported in several studies of confirmed and suspected congenital Zika syndrome cases in humans 21,44,70 . These findings as well as the smaller cerebellum GM volumes may explain the increased incidents of balance loss seen amongst the ZIKV-infected infant RMs during their exploration of a novel social environment.…”
Section: Discussionmentioning
confidence: 88%
“…Infants born with this syndrome can develop seizures, hearing and vision problems, feeding difficulties, and gross motor abnormalities 17 . Importantly, recent reports have documented the postnatal onset of microcephaly, neurologic dysfunction, and neurodevelopmental abnormalities in infants infected prenatally but without overt symptoms at birth [18][19][20][21][22] , highlighting the potential of ZIKV to cause ongoing damage in the postnatal period.…”
Section: Mainmentioning
confidence: 99%
“…Some extrinsic causes in CNS‐linked AMC have been identified, especially congenital infections. Today the most frequent viral infection causing AMC and CNS anomalies is maternal Zika virus infection during pregnancy (C Lage et al, ; Carvalho et al, ). Up to 30% of all newborns present with AMC, with bilateral or unilateral hip, knee, hand and/or feet involvement.…”
Section: Clinical Syndromes and Geneticsmentioning
confidence: 99%