Clinical and MRI evaluation of medium- to long-term results after autologous osteochondral transplantation (OCT) in the knee joint

Žák, Lukáš; Krusche-Mandl, Irena; Aldrian, Silke; Trattnig, Siegfried; Marlovits, Stefan

doi:10.1007/s00167-014-2834-7

Cited by 21 publications

(33 citation statements)

References 32 publications

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“…The average MOCART score after 12 months in our study was 62.4 points, not too much lower than 75 points in Zak et al's study (Zak et al, 2014) and KruscheMandl et al's study (Krusche-Mandl et al, 2012). We also did not find a correlation between MOCART score and function scores or VAS scores.…”

Section: Complicationscontrasting

confidence: 77%

“…Rate of complete defect fill after 1 year according to research by Zak et al is 50% (Zak et al, 2014). In our study, this rate was only 8%; most cases (80%) had defect fill from 50% to <100%.…”

Section: Complicationscontrasting

confidence: 47%

“…In our study, this rate was only 8%; most cases (80%) had defect fill from 50% to <100%. We found intact surface rate of cartilage after 1 year to be 28%; Zak group's found it to be 70% (Zak et al, 2014). This difference may be due to parameters in other studies which are not seen in osteoarthritis patients.…”

Section: Complicationsmentioning

confidence: 46%

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Autologous osteochondral transplantation for treatment of cartilage defects in osteoarthritic knee: preliminary results

Bui

Nguyen

et al. 2016

Biomed Res Ther

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Introduction: Osteoarthritis is a contributing factor for pain and loss of function of the knee. Osteoarthritis results in many damages to the knee; one of the most common damages that is difficult to recover is cartilage injury. This study aims to apply autologous osteochondral transplantation (OAT) under knee arthroscopy for the treatment of knee cartilage defects. Methods: This was a prospective, descriptive and non-controlled study. Patients were diagnosed as having osteoarthritis, as confirmed by 1cm 2 -3cm 2 cartilage defects. Arthroscopic OAT was performed on each patient. Treatment efficacy and safety were evaluated based on Lysholm, Oxford Knee Scores (OKS) and pain scales (VAS) after 3, 6, 12 and 18 months. Results: From 3/2014 -8/2016, 61 cases (54 women and 7 men) participated in the study. The average age was 55 ± 8 years old. Most cases had cartilage defects in the medial condyle. Results showed that Lysholm, OKS scores and VAS scales improved after 12 months of treatment. Of the cases, 33 of 61 were followed out to 18 months; these patients showed improvement in knee function and pain scores. There was 1 case with incomplete matching between the plug and receiving site and 1 case with a broken plug. At the final stage of monitoring, there were no patients who experienced complications, such as broken instruments or fracture of condyle, nor who experienced early postoperative complications, such as infection and bleeding. Conclusion: Autologous osteochondral transplantation via arthroscopy is a safe and promising method for the treatment of knee cartilage defects in patients with average osteoarthritis.

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Section: Complicationscontrasting

confidence: 77%

Section: Complicationscontrasting

confidence: 47%

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Autologous osteochondral transplantation for treatment of cartilage defects in osteoarthritic knee: preliminary results

Bui

Nguyen

et al. 2016

Biomed Res Ther

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“…De acordo com Yusuf et al (2011), quase todas as lesões subcondrais podem mudar de tamanho e de características ao longo de um período de 3 meses. Em um estudo realizado em humanos, após a utilização de enxerto osteocondral autógeno em casos de osteocondrite, constatou-se por meio da RM, que as alterações no osso subcondral como cistos, esclerose ou tecido de granulação ocorreram em até sete anos após o procedimento (Zak et al 2014).…”

Section: Discussionunclassified

“…A técnica de enxertia osteocondral de origem autógena possibilita o preenchimento do defeito articular com cartilagem hialina própria e livre de reações imunológicas presentes nos enxertos homólogos (Hattori et al 2007, Krusche-Mandl et al 2012, Zak et al 2014, além disso, permite a criação de uma barreira imediata entre o fluido sinovial e osso subcondral, e a reconstituição da superfície articular e da capacidade de suporte de carga do osso subcondral (Bodo et al 2004, Fitzpatrick et al 2010. A restauração do contorno e da congruência articular é desejável na realização do procedimento de enxertia osteocondral, pois influencia de forma direta a função do enxerto e os resultados do tratamento (Cook et al 2008, Böttcher et al 2010.…”

Section: Introductionunclassified

Ressonância magnética na avaliação de enxerto osteocondral autógeno na cartilagem articular de coelhos

et al. 2017

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ABSTRACT. - This study aimed to determine the characteristics and applicability of magnetic resonance imaging (MRI) in the evaluation of autogenous osteochondral graft in intact or macerated format, with or without insulin-like growth factor type 1 (IGF-1) used in repair of cartilage lesions induced in rabbits. Nine New Zealand rabbits were used, in which 18 stifle joints underwent grafting procedure in the femoral trochlear groove. These were divided into four groups, referred as intact osteochondral graft + IGF-1 (n=5), intact osteochondral graft + saline solution (n=4), macerated osteochondral graft + IGF-1 (n=5) and macerated osteochondral graft + saline solution (n=4). Animals were euthanized 12 weeks after surgery and the joints were subjected to MRI using a high magnetic field scanner of 1.5 Tesla. In addition, samples of grafting sites were subjected to anatomopathological examination. The MRI was effective as a noninvasive method to evaluate the repair tissue in osteochondral grafts in articular cartilage of the femur of rabbits by providing complementary data to macroscopic and histological examinations. Through these images and anatomopathological examinations satisfactory results were observed in relation to the repair process of autogenous osteochondral grafts in cartilage of rabbits, regardless of its format or the addition of IGF-1. RESUMO.-Este trabalho teve o objetivo de determinar as características e a aplicabilidade do exame de ressonância magnética na avaliação de enxerto ostecondral autógeno, em formato íntegro ou macerado, associado ou não ao fator de crescimento semelhante à insulina tipo 1 (IGF-1), utilizado no reparo de lesões induzidas na cartilagem articular de coelhos. Foram utilizados 9 coelhos da linhagem Nova Zelândia, em que as 18 articulações fêmoro-tíbio-patelares foram submetidas à enxertia osteocondral autógena no sulco troclear femoral. Estas foram divididas em quatro grupos, denominados como enxerto osteocondral íntegro + IGF-1 (n=5), enxerto osteocondral íntegro + solução fisioló-gica (n=4), enxerto osteocondral macerado + IGF-1 (n=5) e enxerto osteocondral macerado + solução fisiológica (n=4). Os animais foram eutanasiados em 12 semanas após a cirurgia e as articulações foram submetidas ao exame de ressonância magnética utilizando um aparelho scanner de 1,5 Tesla de alto campo magnético. Além disso, amostras dos locais de enxertia foram submetidas aos exames anatomopatológicos. O exame de ressonância magnética mostrou--se eficaz como um método não invasivo para avaliação do tecido de reparação em enxertos osteocondrais na cartilagem articular do fêmur de coelhos, fornecendo dados complementares aos exames macroscópicos e histológicos. Por

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Osteochondral Autograft Transfer

Chen

Heller

Mullen

et al. 2018

Cartilage Restoration

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Clinical and MRI evaluation of medium- to long-term results after autologous osteochondral transplantation (OCT) in the knee joint

Abstract: Retrospective therapeutic study, Level IV.

Cited by 21 publications

References 32 publications

Autologous osteochondral transplantation for treatment of cartilage defects in osteoarthritic knee: preliminary results

Autologous osteochondral transplantation for treatment of cartilage defects in osteoarthritic knee: preliminary results

Ressonância magnética na avaliação de enxerto osteocondral autógeno na cartilagem articular de coelhos

Osteochondral Autograft Transfer

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