Clinical and Laboratory Studies of Ectopic Humoral Syndromes

Liddle, Grant W.; Nicholson, Wendell E.; Island, Donald P.; Orth, David N.; Abe, Kaoru; Lowder, Stephen C.

doi:10.1016/b978-0-12-571125-8.50009-0

Cited by 148 publications

(85 citation statements)

References 77 publications

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“…Many ofthese difficulties center around the ectopic ACTH syndrome, in which ACTH is secreted by an extrapituitary tumor. Characteristically, POMC gene expression and ACTH secretion is unaltered by glucocorticoids, in contrast to corticotroph adenomas ofthe pituitary (1). In addition, limited processing of POMC results in the secretion of high molecular weight precursor forms of ACTH (2).…”

mentioning

confidence: 99%

Bromocriptine inhibits pro-opiomelanocortin mRNA and ACTH precursor secretion in small cell lung cancer cell lines.

Farrell¹,

Clark²,

Stewart³

et al. 1992

J. Clin. Invest.

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mentioning

confidence: 99%

Bromocriptine inhibits pro-opiomelanocortin mRNA and ACTH precursor secretion in small cell lung cancer cell lines.

Farrell¹,

Clark²,

Stewart³

et al. 1992

J. Clin. Invest.

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“…Partial characterization of the corticotropin extracted from tumors of patients with the ectopic adrenocorticotropic hormone (ACTH)1 syndrome (1,2) has shown it to be very similar to pituitary corticotropin in a variety of biologic, physicochemical, and immunologic test systems (3,4). The precise structure of the tumor hormone has not been determined, however.…”

Section: Introductionmentioning

confidence: 99%

Biologic and Immunologic Characterization and Physical Separation of ACTH and ACTH Fragments in the Ectopic ACTH Syndrome

Orth¹,

Nicholson²,

Mitchell³

et al. 1973

J. Clin. Invest.

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104

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A B S T R A C T Extracts of tumors from 32 patients with the ectopic ACTH syndrome were subjected to simultaneous bioassay and radioimmunoassays for ACTH. Radioimmunoassays were performed using three antisera, one of which reacts with the extreme N-terminal 1-13 amino acid sequence of ACTH, the second with the N-terminal 1-23 sequence of the ACTH molecule, and the third with the C-terminal 25-39 amino acid sequence of ACTH. There was, in general, good correlation between bioactivity and N-terminal ACTH immunoreactivity. However, there were large excesses of both extreme N-terminal and C-terminal immunoreactive materials in most tumor extracts, which were not found in extracts of three human pituitaries. Three tumor extracts were subjected to molecular sieve chromatography on Sephadex G-50 fine resin. The bioactive ACTH eluted in the same fractions as pituitary ACTH (mol wt

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“…It was not until the 1960s that a connection was made between ACTH-dependent CS and certain non-pituitary tumors. It was recognized that neoplasms may acquire the ability to secrete substances not normally secreted from the tissue in which they originate [3]. Ectopic ACTH production resulting in CS is associated with a variety of solid tumors, mostly of neuroendocrinologic origin [4].…”

Section: Discussionmentioning

confidence: 99%

Role of Adrenalectomy in Ectopic ACTH Syndrome

Yan

Mao

et al. 2005

Endocr J

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Abstract. Evaluation of adrenalectomy in patients diagnosed with ectopic ACTH syndrome was studied. Twenty-three clinical cases diagnosed with ectopic ACTH syndrome were analyzed at Chinese Academy of Medical Sciences and Peking Union Medical College Hospital (PUMCH). Cases consisted of 14 males and 9 females, with mean age of 38 years. All 23 cases had positive clinical, biochemical and radiology evidence for diagnosis of Cushing's syndrome. Sixteen of the 23 cases were treated with total adrenalectomy and the remaining 7 were treated without surgical intervention. Sixteen cases, having no identifiable source of ectopic hormone production, experienced resolution of presenting signs and symptoms after undergoing bilateral or unilateral total adrenalectomy; 1-year survival was 67%, 2-year survival 41% and 5-year survival 15%. In patients treated conservatively without surgical intervention, 1-year survival was 0%. In patients with no identifiable source of ectopic hormone production, bilateral adrenalectomy followed by hormone replacement treatment is effective.

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Clinical and Laboratory Studies of Ectopic Humoral Syndromes

Cited by 148 publications

References 77 publications

Bromocriptine inhibits pro-opiomelanocortin mRNA and ACTH precursor secretion in small cell lung cancer cell lines.

Bromocriptine inhibits pro-opiomelanocortin mRNA and ACTH precursor secretion in small cell lung cancer cell lines.

Biologic and Immunologic Characterization and Physical Separation of ACTH and ACTH Fragments in the Ectopic ACTH Syndrome

Role of Adrenalectomy in Ectopic ACTH Syndrome

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