Clinical and Laboratory Presentations of Leptospirosis Patients in North of Iran

Abstract

Leptospirosis is a zoonosis that common in warm and tropical regions with global spread and it is an occupational disease. The aim of recent study was to evaluate the clinical and Para clinical findings of leptospirosis patients in Babol, northern of Iran. In this cross-sectional study, 118 patients with high suspicion to leptospirosis admitted to hospitals of Babol University of Medical Sciences, Babol, Iran, during 2009 -2011. Thirty one cases with positive finding (IFA) were enrolled as definitive Patients. Clinical and Para clinical data for all patients were recorded. The mean age of the confirmed patients (male: 71%, rural: 90.5%) was 48.5 years (range 18-80 years old). The commonest chief complaints were fever (71%) and ichter (19%) and among the clinical features of them fever (90.5%), gastro intestinal signs (80.5%), ichter (71%) and headache(68%) was the most prevalent ones. Weil's syndrome occurred in 10 (32%) patients. Thrombocytopenia and leukocytosis were noticed in 80.5% and 42% of the patients respectively. Transaminases in 80.5% of cases were above the normal upper limit. Based on current study, the most of leptospirosis patients were farmers and presented in hot seasons. The commonest clinical and laboratory pattern of this disease in our region was fever, ichter, myalgia and headache in conjunction with Mild elevations in levels of transaminases and thrombocytopenia that can be used as a good marker in early clinical diagnosis and treatment.