Clinical and immunological allergy assessment in cancer patients

Carneiro, Bruno Gustavo Muzzi Carvalho e; Petroianu, Andy; Machado, José Augusto Nogueira; Anjos, Paula Martins Ferreira dos; Silva, Fabiana Rocha da; Alberti, Luiz Ronaldo; Resende, Vívian; Barrientos, Sofia Candia

doi:10.1038/s41598-021-97200-y

Cited by 8 publications

(9 citation statements)

References 60 publications

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“…However, Carneiro et al. reported that IL-17 levels in stomach patients were lower than that in the control group (median: 404.2 vs. 573.9 pg/ml, P <0.004) ( 37 ). Our MR analysis found an inverse association of circulating IL-17 levels and the risk of stomach cancer.…”

Section: Discussionmentioning

confidence: 99%

Genetically Predicted Circulating Levels of Cytokines and the Risk of Cancer

Song

et al. 2022

Front. Immunol.

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BackgroundInflammation plays a pivotal role in the pathogenesis of cancer. Though previous studies have reported a link between several inflammatory biomarkers and risk of certain types of cancer, there is a lack of systematic investigation. Therefore, we aimed to assess the role of circulating cytokines on the risk of cancer using a two-sample Mendelian randomization (MR) approach.MethodWe used genetic variants associated with circulating levels of cytokines from a meta-analysis of genome-wide association studies (GWASs) of 8,293 Finns as instrumental variables. Summary level data of 20 site-specific cancer were obtained from the UK BioBank including up to 456,348 participants of European ancestry. We performed two-sample MR analyses using inverse-variance weighted (IVW) method as the main method, followed by weighted-median and likelihood-based methods as sensitivity analysis. Pleiotropic and outlier variants were assessed by MR-Egger regression and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test.Results224 genetic variants associated with 27 circulating cytokines achieving genome-wide significance (P<5×10-8) were used as IVs. After Bonferroni correction, genetically predicted high levels of interleukin-18 (IL-18) were associated with a decreased risk of acute myeloid leukemia (odds ratio (OR) per 1 standard deviation (SD) increase = 0.55, 95% confidence interval (CI):0.43-0.69, P=5.39×10-7), and circulating levels of IL-17 were associated with altered stomach cancer risk (OR per 1 SD increase = 0.15, 95% CI: 0.07-0.36, P=1.25×10-5) by IVW. Results were stable across sensitivity analyses, and MR-Egger regression did not suggest the presence of directional pleiotropy. Additionally, we found suggestive evidence for 48 cytokine-cancer associations including tumor necrosis factor related apoptosis-inducing ligand (TRAIL) and cutaneous T-cell attracting chemokine (CTACK) with the risk of several types of cancer (9.26×10-5≤P<0.05).ConclusionsBy using a genetic epidemiological approach, our study systematically evaluated the role of circulating cytokines on the risk of cancer, and provided clues for potential therapeutic targets. However, the exact underlying biological mechanism warrants further investigation.

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Section: Discussionmentioning

confidence: 99%

Genetically Predicted Circulating Levels of Cytokines and the Risk of Cancer

Song

et al. 2022

Front. Immunol.

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“…A substantial amount of data, however, has been accumulated, indicating that those working in the occupations with a high degree of fungal exposure generally have a higher rate of cancer [ 5 , 62 , 63 , 64 , 65 ]. In contrast, while somewhat controversial [ 66 , 67 , 68 , 69 , 70 , 71 , 72 ], individuals with allergy-related diseases and asthma have been reported to generally have a lower rate of cancer, including leukemia and a variety of solid tumors, as compared to the general population [ 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ]. Some epidemiological data indicates potential roles for IgE, allergy, and atopy in protecting against certain tumors [ 85 , 86 ].…”

Section: Introductionmentioning

confidence: 99%

Mycoviruses in Fungi: Carcinogenesis of Fungal Agents May Not Always Be Mycotoxin Related

Tebbi¹

2023

JoF

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Certain viruses have been found to induce diverse biological pathways to carcinogenesis, evidenced by the presence of viral gene products in some tumors. Despite the fact that many fungal agents contain mycoviruses, until recently, their possible direct effects on human health, including carcinogenesis and leukemogenesis, had not been explored. In this regard, most studies of fungal agents have rightly concentrated on their mycotoxin formation and effects. Recently, the direct role of yeasts and fungi in the etiology of cancers, including leukemia, have been investigated. While greater attention has been placed on the carcinogenic effects of Candida, the role of filamentous fungi in carcinogenesis has also been explored. Recent findings from studies using the enzyme-linked immunosorbent assay (ELISA) technique indicate that the plasma of patients with acute lymphoblastic leukemia (ALL) uniformly contains antibodies for a certain mycovirus-containing Aspergillus flavus, while controls are negative. The exposure of mononuclear leukocytes from patients with ALL in full remission, and long-term survivors, to the product of this organism was reported to result in the re-development of typical genetics and cell surface phenotypes characteristic of active ALL. Mycoviruses are known to be able to significantly alter the biological characteristics and functions of their host. The possible carcinogenic and leukemogenic role of mycoviruses, with and without their host, needs to be further investigated.

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“…The presence, specificity, and isotype distribution of Igs in patients with cancer likely have an impact on tumour progression and could potentially inform on early detection of cancer and even predict the survival of the patient [ 6 , 11 ]. Procedures to test the presence of antibodies, especially serum antibodies, are minimally invasive and easy to measure, and for this they harbour potential as biomarkers for cancer.…”

Section: Introductionmentioning

confidence: 99%

Antibodies as biomarkers for cancer risk: a systematic review

Crescioli

Beckmann

Lê

et al. 2022

Clinical and Experimental Immunology

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Summary Increasing evidence has linked the humoral immune response with the development of various cancers. Therefore, there is growing interest in investigating the predictive value of antibodies to assess overall and tissue site-specific cancer risk. Given the large amount of antibody types and the broad scope of the search (i.e., cancer risk), the primary aim of this systematic review was to present an overview of the most researched antibodies (i.e., immunoglobulin (Ig) isotypes (IgG, IgM, IgA, IgE), tumour and self antigen-reactive antibodies, infection-related antibodies) in relation to overall and site-specific cancer risk. We identified various antibody types that have been associated with the risk of cancer. While no significant associations were found for IgM serum levels, studies found an inconsistent association between IgE, IgA and IgG serum levels in relation to cancer risk. When evaluating antibodies against infectious agents, most studies reported a positive link with specific cancers known to be associated with the specific agent recognised by serum antibodies (i.e., helicobacter pylori and gastric cancer, hepatitis B virus and hepatocellular carcinoma, human papilloma virus and cervical cancer). Several reports identified autoantibodies, as single biomarkers (e.g., anti-p53, anti-MUC1, anti-CA125) but especially in panels of multiple autoantibodies, to have potential as diagnostic biomarkers for specific cancer types. Overall, there is emerging evidence associating certain antibodies to cancer risk, especially immunoglobulin isotypes, tumour-associated antigen-specific and self-reactive antibodies. Further experimental studies are necessary to assess the efficacy of specific antibodies as markers for early diagnosis of cancer.

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Clinical and immunological allergy assessment in cancer patients

Cited by 8 publications

References 60 publications

Genetically Predicted Circulating Levels of Cytokines and the Risk of Cancer

Genetically Predicted Circulating Levels of Cytokines and the Risk of Cancer

Mycoviruses in Fungi: Carcinogenesis of Fungal Agents May Not Always Be Mycotoxin Related

Antibodies as biomarkers for cancer risk: a systematic review

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