Clinical and histopathologic spectrum of necrotizing vasculitis. Report of findings in 101 cases

Sanchez, N. P.

doi:10.1001/archderm.121.2.220

Cited by 60 publications

(55 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A careful reading of previous reports shows similar percentages. [7][8][9][10] The prevalence of HCV in the Spanish population is 0.8%, and this can explain the high incidence of LV associated with HCV in our series (21.4%). In almost 47% of our patients, cutaneous LV resolved in less than 6 months, and a subgroup of patients (8%) presented with successive crops of cutaneous lesions for more than 10 years.…”

Section: Commentmentioning

confidence: 57%

“…The natural course of the cutaneous lesions is unpredictable. [7][8][9][10] The diagnosis of LV includes a heterogeneous group of patients having different vasculitic syndromes, with multiple known causes and associated conditions. 3,4,[10][11][12][13][14][15][16][17][18][19][20][21] Risk factors to distinguish patients with a poor prognosis from those with a benign course have not been identified, and a rational therapy has not been standardized in this disorder.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic Factors in Leukocytoclastic Vasculitis

Sais¹,

Vidaller²,

Jucglà³

et al. 1998

Arch Dermatol

138

View full text Add to dashboard Cite

Section: Commentmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Prognostic Factors in Leukocytoclastic Vasculitis

Sais¹,

Vidaller²,

Jucglà³

et al. 1998

Arch Dermatol

138

View full text Add to dashboard Cite

“…Our patient responded promptly to the administration of corticosteroids and maintained remission for 3 years, similar to previous reports in the literature. Although cutaneous leukocytoclastic vasculitis is a non specific manifestation of a wide variety of pathologic processes [16] the other features of this syndrome taken together (systemic upset, abdominal pain, and the distribution of arthritis and skin lesions) are diagnostic, and their recognition may prevent the need to undertake exhaustive investigations.…”

Section: Resultsmentioning

confidence: 99%

Bowel-associated dermatosis-arthritis syndrome: A case report

2009

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

We report a rare case of Bowel Associated Dermatosis -Arthritis Syndrome in a young patient with complex Crohn's disease who presented with fever, arthritis, rash and worsening of diarrhea with abdominal pain, who promptly responded to a short course of steroids. Case PresentationA 23 year old white male with a 4 year history of Crohn's disease presented with an acute two day history of malaise, fever, abdominal pain, vomiting and stomal diarrhoea. He complained of joint pains affecting the shoulders, elbows, wrists, metacarpophalangeals, knees and ankles. There was also a rash on the elbows, ankles and feet, which began as erythematous macules and evolved to vesico-pustular lesions followed by crusting. There was no history of sexual exposure or any intercurrent infection. He was on no regular medication, but had discontinued Pentasa 4 months earlier.One month earlier he had undergone a laparotomy to excise a complex ileo-cutaneous fistula with blind tracts, and two weeks earlier a defunctioning ileostomy had been created in view of persistent abdominal pain. The cutaneous fistula had been present for a year, but was associated with a terminal ileal stricture and ileo-rectal fistula of at least 2 years duration. His bowel disease had been resistant to immunosuppressive drugs including azathioprine, corticosteroiods and three infusions of Infliximab a year earlier. There had been no extra-intestinal manifestations.On admission to the hospital, he was thin, afebrile with a resting tachycardia of 125/minute. The rest of the cardiorespiratory examination was normal. The abdomen was minimally tender around the ileostomy without guarding or rebound tenderness. Examination of the skin revealed some pustules and crusts around the elbows, ankles and feet (Fig 1 and 2). The buttocks were spared. There were clinical signs of synovitis of the wrists, proximal interphalangeal and metacarpophalangeal joints, and also both ankles.Results of the laboratory tests showed a haemoglobin of 13.1 gm/dl, white blood count 15.8 × 10 9 /L, platelets 585 × 10 9 /L, C-reactive protein 37.7 mg/L and erythrocyte sedimentation rate 69 mm/hr. Urea and electrolytes, complement, urine analysis and microscopy were normal. Rheumatoid factor, antinuclear and antineutrophil cytoplasmic antibodies, cryoglobulins and Hepatitis B and C serology were negative. Transthoracic echocardiogram showed no signs of endocarditis, and multiple blood cultures were sterile. A skin biopsy from the ankle revealed a perivascular lymphohistiocytic infiltrate with prominent neutrophils and associated fibrinoid necrosis of vessels consistent with 'leukocytoclastic' vasculitis.He was commenced on 60 mg prednisolone per day leading to prompt and complete resolution of all features. The dose of prednisolone was rapidly tapered over the course

show abstract

“…Os órgãos mais acometidos são rins, articulações, pulmões, cérebro e trato gastrointestinal 3 . Os achados laboratoriais mais comuns incluem alterações na velocidade de hemossedi-mentação (VHS) e urinálise, leucocitose leve com ou sem eosinofilia, fator reumatóide (FR) positivo e fator antinuclear (FAN) positivo 4 . Manifestações oftalmológicas da VLCC são raras, porém há relatos sugerindo associação com uveíte, retinite multifocal, episclerite, pseudotumor cerebral, e atrofia óptica 5 .…”

Section: Introductionunclassified

“…Fábio Henrique Cacho Casanova (1) Rodrigo L. Meirelles (1) Marcelo Tojar (2) Maria Cristina Martins (3) Moacir P. Rigueiro (4) Denise de Freitas (5) RESUMO Palavras-chave: Vasculite leucocitoclástica; Ceratólise; Erythema elevatum diutinum; Perfuração ocular.…”

unclassified

Ceratólise auto-imune em paciente com vasculite leucocitoclástica: apresentação atípica de erythema elevatum diutinum com padrão granulomatoso

Casanova¹,

Meirelles²,

Tojar³

et al. 2000

Arq. Bras. Oftalmol.

View full text Add to dashboard Cite

Ceratólise auto-imune em paciente com vasculite leucocitoclástica: apresentação atípica de erythema elevatum diutinum com padrão granulomatoso Contexto: A vasculite leucocitoclástica é uma doença que acomete pequenos vasos mais comumente associada a distúrbios do tecido conectivo, caracterizada clinicamente pela presença de lesões purpú-ricas palpáveis. Manifestações oftalmológicas são raras.Objetivo: Descrever quadro clínico de paciente portador de vasculite leucocitoclástica como manifestação incomum de padrão granulomatoso do erythema elevatum diutinum (EED).Relato de Caso: Paciente de 64 anos, masculino, apresentando baixa de acuidade visual e aparecimento de lesões nodulares em mãos. Ao exame oftalmológico, evidenciou-se afinamento corneano superior bilateral com perfuração corneana do olho esquerdo e espessamento da conjuntiva limbar em ambos os olhos, associada a intensa atividade inflamatória. Exame anatomopatológico da conjuntiva revelou vasculite granulomatosa com intenso exsudato neutrofílico, células gigantes multinucleadas, além de proliferação fibroblástica. Exame anatomopatológico de biopsia da pele evidenciou alterações semelhantes compatíveis com EED, porém não foi visto célula gigante sugerindo lesão granulomatosa.Conclusão: Ceratólise auto-imune secundária a vasculite leucocitoclástica cutânea (EED) não havia sido descrito na literatura, tampouco encontramos referências sobre a reação granulomatosa (encontrada na conjuntiva) em EED. Autoimmune keratolysis in a patient with leucocytoclastic vasculitis: unusual erythema elevatum diutinum with granulomatous patternUniversidade Federal de São Paulo -Escola Paulista de Medicina. INTRODUÇÃOA vasculite leucocitoclástica (VLCC), conhecida também como vasculite alérgica, angiíte por hipersensibilidade e vasculite necrotizante, é uma doença que acomete pequenos vasos (vênulas pós-capilares) mediada por imunocomplexos. É mais comumente associada a distúrbios do tecido conectivo, caracterizada clinicamente pela presença de lesões cutâneas purpúricas palpáveis mais freqüentemente localizadas nas extremidades inferiores 1 . Aproximadamente 50% dos pacientes têm envolvimento de pelo menos um órgão além da pele 2 . Os órgãos mais acometidos são rins, articulações, pulmões, cérebro e trato gastrointestinal 3 . Os achados laboratoriais mais comuns incluem alterações na velocidade de hemossedi-

show abstract

Clinical and histopathologic spectrum of necrotizing vasculitis. Report of findings in 101 cases

Cited by 60 publications

References 0 publications

Prognostic Factors in Leukocytoclastic Vasculitis

Prognostic Factors in Leukocytoclastic Vasculitis

Bowel-associated dermatosis-arthritis syndrome: A case report

Ceratólise auto-imune em paciente com vasculite leucocitoclástica: apresentação atípica de erythema elevatum diutinum com padrão granulomatoso

Contact Info

Product

Resources

About