1988
DOI: 10.1001/archderm.124.2.216
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Clinical and histologic heterogeneity of psoriatic plaques. Therapeutic relevance

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1989
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Cited by 13 publications
(10 citation statements)
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“…Conventional skin biopsy with H&E staining may provide the best qualitative microscopic information that could be used for evidence-based assessment. Some histopathological studies of psoriasis have examined the differences in histopathological findings before and after treatment 8 , 9 , the changes in histopathological findings according to the evolution of psoriatic lesions 10 , 11 , 12 , and the clinical types of psoriasis 13 . The information from these studies was limited because they were not designed for the quantitative grading of psoriasis severity based on histopathology.…”
Section: Discussionmentioning
confidence: 99%
“…Conventional skin biopsy with H&E staining may provide the best qualitative microscopic information that could be used for evidence-based assessment. Some histopathological studies of psoriasis have examined the differences in histopathological findings before and after treatment 8 , 9 , the changes in histopathological findings according to the evolution of psoriatic lesions 10 , 11 , 12 , and the clinical types of psoriasis 13 . The information from these studies was limited because they were not designed for the quantitative grading of psoriasis severity based on histopathology.…”
Section: Discussionmentioning
confidence: 99%
“…Two psoriatic scale samples showed exceedingly high GM-CSF levels, indicating heterogeneity of psoriatic lesions [34]. Another possibility is that, while scales of érythrodermie and pustular psoriasis are easily scraped off from the skin, scales of psoriasis vulgaris usually pile up onto the skin lesions, which may lead to increased trapping of secreted proteins within the lcsional stratum corneum.…”
Section: Discussionmentioning
confidence: 99%
“…Our findings are in sharp contrast with the above studies. Griffin TD et al described exocytosis of neutrophils as a histopathological feature of acute psoriasis while chronic psoriatic plaques lack the presence of neutrophils [27]. The finding of neutrophil exocytosis appears to be a variable finding and may be limited to early or late stage.…”
Section: Discussionmentioning
confidence: 99%