2018
DOI: 10.1136/bmjopen-2017-020759
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Abstract: ObjectivesWithin the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.Research design and methodsFour hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Following adjustments for possible confounder… Show more

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Cited by 15 publications
(13 citation statements)
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“…In this study, a significant association of eNOS and MCP-1 genotypes with BMI, urea, creatinine and random blood sugar levels was observed. Experimental evidences have suggested that levels of urea, creatinine and glucose levels are involved in increased insulin resistance and promote the progression of renal disease in T2D patients (Neumiller and Hirsch 2015 ; Kashima et al 2017 ; Li et al 2018 ; Osman et al 2018 ; Xie et al 2018 ; Zaman et al 2018 ; Davies et al 2018 ). Although there are few studies available on the association of eNOS and MCP-1 genotypes with T2D and DN phenotypes, these studies have not deciphered the association of these genotypes with BMI, urea, creatinine and random blood sugar levels (Joo et al 2007 ; Hassan et al 2010 ; Moguib et al 2017 ; Sadati et al 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…In this study, a significant association of eNOS and MCP-1 genotypes with BMI, urea, creatinine and random blood sugar levels was observed. Experimental evidences have suggested that levels of urea, creatinine and glucose levels are involved in increased insulin resistance and promote the progression of renal disease in T2D patients (Neumiller and Hirsch 2015 ; Kashima et al 2017 ; Li et al 2018 ; Osman et al 2018 ; Xie et al 2018 ; Zaman et al 2018 ; Davies et al 2018 ). Although there are few studies available on the association of eNOS and MCP-1 genotypes with T2D and DN phenotypes, these studies have not deciphered the association of these genotypes with BMI, urea, creatinine and random blood sugar levels (Joo et al 2007 ; Hassan et al 2010 ; Moguib et al 2017 ; Sadati et al 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…They result in glomerular epithelial hypertrophy and tubular and glomerular basement membrane thickening, and culminate in interstitial fibrosis and glomerulosclerosis [ 13 ]. Renal function worsens over time in patients with DKD, and even the most optimal approach to glycemic control becomes ineffective as renal function deteriorates [ 14 ]. This scenario occurs irrespective of age, and older adults may be particularly vulnerable to the development of DKD due to the impairment of organ reserves and the presence of other comorbidities.…”
Section: Discussionmentioning
confidence: 99%
“…Our study has identified R-spondins as regulators that maintain the nephrogenic niche during development and we can speculate that changes in expression levels or protein function in these genes may be associated with renal disorders. Interestingly, the RSPO3 locus has been identified in two studies to be linked with renal diseases including abnormal blood urea nitrogen (BUN), a hallmark for glomerular filtration dysfunction 37,38 . Given these studies and our findings mice, it will be of interest to further investigate a potential role of R-spondin variants in the predisposition to renal disease.…”
Section: Discussionmentioning
confidence: 99%