Clinical and epidemiological analysis of basosquamous carcinoma: results of the multicenter study

Abstract

Basosquamous carcinoma (BSC) is a rare non-melanoma skin cancer that shares the characteristic features of both basal and squamous cell carcinomas (BCC, SCC). Our research enables better characterization of BSC in comparison to high-risk subtypes of BCC and SCC. Paper includes a retrospective analysis of BSC cases regarding sex, age, number of tumors and anatomical distribution in comparison to BCC and SCC evaluating the differences and defining the implications. Histologically confirmed carcinomas recorded between 1999 and 2019 were studied. 181 diagnosed BSC cases were identified, making this study the largest cohorts of BSC patients reported worldwide. Most cases were reported on head and neck. Analysis of facial anatomic distribution shows that most commonly affected sites were the nose (43%) and the cheek (25%). The age at excision of metatypical BCC was higher than those of low-risk BCC (P < 0.05), however similar to high-risk BCC (P = 0.20). We revisited that the concept of BSC is the most similar to high-risk subtypes of BCC. Patients with diagnosed BSC have higher risk of second nonmelanoma skin cancer. Therefore, the frequency of follow-up examination should be adjusted to the individual risk of another skin cancer.

The incidence and clinical analysis of non-melanoma skin cancer

“…All consecutive patients aged 18 years old and above (those centres do not treat children) with histopathologically confirmed BCC or SCC were included in the study. The database and methods were conducted similarly to our previous study 10 .…”

“…We also extracted data regarding incidence rates of NMSC between 1999 and 2019 from the Polish National Health Fund database registries using C44.0–C44.9 of ICD-10 coding and compared them to our data 10 .…”

“…The data used encrypted identification of the subjects, thus written consent was not required from the patients. All procedures and methods were conducted in accordance Declaration of Helsinki 10 .…”

Basal cell carcinoma‑not always the ‘good guy’: Case report of a life‑threatening basosquamous carcinoma and review of the literature

“…Ultraviolet radiation (UVR) is known to be the prevalent risk factor for BCC, SCC, and therefore BSC (23) with a preferential localization on the sun-exposed areas, especially the head and neck region (3). Moreover, it appears that BSC occurs more frequently in men (3,24) in the six to eight decades of life (24) with a mean age at diagnosis of 72±11.5 years (3).…”

“…As with any other BCC, it presents as a plaque, papule, or nodule with an ulcerating potential. Elderly, fair-skinned white men are the most affected, especially on the head and neck area (3). Dermoscopy shows polymorphous vascular structures typical of BCC combined with scaling, ulceration, white circles and white structureless areas (4,5).…”