Clinical analysis of Kimura’s disease in 24 cases from China

Abstract

Background: We reviewed details of Chinese Kimura’s disease (KD) cases. A full clinical analysis was subsequently performed to improve the accuracy of clinical diagnosis and treatment of KD. Methods: A total of 24 patients with pathologically confirmed KD treated between March 2008 and March 2018 were reviewed retrospectively for clinical and histopathological analysis. Results: In the 24 KD cases, 20 were male and 4 were female with the age of onset ranging from 5 to 65 years. Lesion diameter ranged from 0.6 cm to 7 cm with unilateral involvement being more popular (79%). Imaging examination had a high detection rate for KD involving the parotid gland and subcutaneous but had low specificity. Microscopic analysis indicated that KD mainly involved subcutaneous soft tissue and lymph nodes. The prominent feature of lymphoid tissue was germinal center hyperplasia surrounded by several lobules associated with hyperplastic vascular structures. Out of the 24 patients, 11 experienced recurrence of disease after treatment (surgical resection: 46.2%, surgical resection followed by oral corticosteroids: 71.4% and surgical resection combined with radiotherapy: 0%). Conclusions: Our analysis revealed clinical, imaging, and histological characteristics of KD. A better understanding of the disease will help clinicians reduce misdiagnosis and improve the diagnostic rate upon patient first clinical visit.

Kimura disease of the breast: Case report and literature review of current management

“…To date, there have only been 200 reported incidences of Kimura disease globally, 2 and only 1 reported case of Kimura Disease of the Breast in 2016 3 . Kimura disease predominantly occurs in Asian male populations, with incidence peaking around the second and third decade of life 4,5 …”

“…Patients commonly present with a palpable unilateral lump in their head and neck region including the salivary glands, but other regions including the axilla, groin, and arm have also been reported 2,4 . About 10 to 60% of patients with Kimura disease suffer from concurrent nephrotic syndrome, 5 with biopsies showing a membranous glomerulonephritis and mesangial proliferation, eosinophilic interstitial infiltrates, and some podocytic foot process effacement 9…”

Kimura’s disease mimicking thoracic spine dumbbell neurogenic tumor: a case report and literature review

“…[ 41 ] 1 2015 Chinese Male 47 5 in diameter cervical, subaxillary and inguinal region prednisone 0.5 mg/kg/day, thalidomide 50 mg/day no 26.11% 1081.34 recurrent tapering of prednisolone 36 Wang, H. [ 42 ] 1 2016 Chinese Male 72 / head surgical excision, Chinese herbal remedies, cetirizine hydrochloride and olmesartan 20 mg/day, gamma immunoglobulin 10 g/day for 5 days, intravenous pulse methylprednisolone therapy 500 mg for 3 days, hydroxychloroquine 0.4 g/day, prednisone 50 mg/day, a single dose of intravenous cyclophosphamide 500 mg yes 35% 149,000 recurrent / 43 Matsuo, T. [ 11 ] 1 2017 Japanese Male 42 / head surgical excision, prednisone 40 mg/day, cyclosporine 75 mg/day yes 9.40% 735 recurrent tapering of prednisolone 82 Chakraborti, C. [ 43 ] 1 2019 / Female 23 2.5 × 2.5 × 1 head and neck prednisolone 40 mg no 30% 262.64 recurrent / 2 Li, X. [ 44 ] 1 2019 Chinese Male 48 15 × 10 × 3, 5 × 5 × 2, 4 × 3 × 2, 4 × 3 × 1 head and neck surgical excision, 25 mg prednisone twice daily no 0.55% 27,100 recurrent / 0.5 Zhang, G. [ 45 ] ...…”

Kimura’s disease as an uncommon cause of post auricular swelling

“…Recurrence rate is as high as 40% despite early treatment of the patients; however there is no consensus for the treatment of recurrent disease with the overall outcome is good as there is no association with malignancy. 19,20 CONCLUSION KD is one of the rarest diseases. However, in all patients presenting with post aural swelling with eosinophilia, KD should be considered as a differential diagnosis to avoid unnecessary diagnostic workup.…”