Clicking Eyelids: A New Finding of Prostaglandin-Associated Periorbitopathy

Skorin, Leonid; Dailey, Kathryn H.

doi:10.1097/opx.0000000000000862

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…Most articles described an association between eyelash trichomegaly and the prostaglandin analogue, bimatoprost, the only Food and Drug Administration approved medication for eyelash growth in the United States (US) 37 . Several articles reported eyelash lengthening as an adverse event (AE) of bimatoprost for treatment of glaucoma 38–43 . Others specifically described the effect of bimatoprost on inducing eyelash trichomegaly.…”

Section: Resultsmentioning

confidence: 99%

Eyelash trichomegaly: a systematic review of acquired and congenital aetiologies of lengthened lashes

Hutchison

Duffens

Yale

et al. 2021

Acad Dermatol Venereol

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Long eyelashes have been popularized and many commercially available products exist to achieve eyelash growth as a desired cosmetic effect. Eyelash trichomegaly may be induced by medications, procedures, or be related to medical conditions; however, the exact mechanisms that govern eyelash growth are not well elucidated. This study aims to identify and summarize aetiologies associated with eyelash trichomegaly. We report a systematic review of 148 clinical trials, prospective and retrospective studies, and case reports describing all evidence‐based potential aetiologies of eyelash trichomegaly obtained from the Medline/PubMed and Cochrane Library through January 2021. Inclusion criteria were defined as (i) human studies involving congenital and acquired diseases in which eyelash trichomegaly is a characteristic or (ii) assessment of trichomegaly as an adverse or desired effect of a medication or procedure. Exclusion criteria included: animal studies, articles not available in English, outcomes unrelated to eyelash trichomegaly, and secondary review articles. Pharmacologic agents associated with eyelash trichomegaly included prostaglandin analogues (15‐keto fluprostenol isopropyl ester, bimatoprost, latanoprost, and travoprost), epidermal growth factor receptor inhibitors (cetuximab, erlotinib, and panitumumab), interferon‐alpha, and calcineurin inhibitors (tacrolimus and cyclosporine). Surgical procedures of the eyelid, as well as allergic rhinitis, atopic dermatitis, HIV, ichthyosis vulgaris (IV), uveitis, and vernal keratoconjunctivitis were also associated with increased eyelash growth. Congenital disorders associated with lengthened eyelashes included Cantú syndrome, CHOPS syndrome, Coffin–Siris syndrome, congenital heart disease, Cornelia de Lange syndrome, Costello syndrome, familial trichomegaly, Floating Harbor syndrome, Hermansky–Pudlak syndrome, Kabuki–Makeup syndrome, KBG syndrome, Oliver–McFarlane syndrome, Rubinstein–Taybi syndrome, and Smith–Magenis syndrome. While the most common cause of eyelash trichomegaly is topical bimatoprost use, better understanding of pathways implicated in eyelash trichomegaly may lead to the discovery of additional medications to stimulate eyelash growth and create avenues for future therapeutic interventions.

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Section: Resultsmentioning

confidence: 99%

Eyelash trichomegaly: a systematic review of acquired and congenital aetiologies of lengthened lashes

Hutchison

Duffens

Yale

et al. 2021

Acad Dermatol Venereol

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“…It is the first time we encounter the “click” sound on the blinking in a CS case, possibly due to loss of periorbital fat tissue. Audible clicking blinks have also been scarcely reported in ophthalmology case reports, related to prostaglandin‐associated periorbitopathy with sunken eyes and deepened upper eyelid sulci and these reports hypothesized that periorbital fat atrophy caused by prostaglandin medications was responsible from the clicking sound 13–15 . It has not been described before in CS, and therefore does not have a clear diagnostic value but it may help clinicians in future evaluation of adult‐onset CS.…”

Section: Discussionmentioning

confidence: 99%

Cockayne syndrome type 3 with dystonia‐ataxia and clicking blinks

Gültekin‐Zaim,

Yalçın‐Çakmaklı,

Çolpak

et al. 2023

Movement Disord Clin Pract

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“…Its onset is insidious and is frequently overlooked. PAP can be symptomatic in some patients, even producing an audible clicking sound upon blinking [63,64]. Asymptomatic cases can become problematic at the time of ocular surgery, in that enophthalmos associated with PAP can increase the complexity of intraocular surgery, as well as having implications for patients undergoing oculoplastic surgery.…”

Section: Expert Opinionmentioning

confidence: 99%

Omidenepag isopropyl ophthalmic solution for open-angle glaucoma and ocular hypertension: an update

Aihara

Aung

Bacharach

et al. 2021

Expert Review of Ophthalmology

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Introduction: Current medical therapy for glaucoma consists of topical agents that lower intraocular pressure (IOP). Prostaglandin F2α analogues, the most commonly used class of IOP-lowering drugs, bind to prostaglandin FP receptors in tissues of the uveoscleral pathway. This binding increases the expression of matrix metalloproteinases, which degrade the extracellular matrix of the ciliary body, creating inter-muscular spaces allowing aqueous humor to exit the eye. Drawbacks to prostaglandin F2α analogues include cosmetic side effects, especially prostaglandin-associated periorbitopathy (PAP) syndrome.Areas covered: This review describes the novel prostaglandin E2 receptor antagonist, omidenepag isopropyl, which reduces IOP by improving drainage of uveoscleral and trabecular outflow, increasing the facility of outflow. In contrast to prostaglandin F2α analogues, omidenepag does not inhibit adipogenesis or promote eyelash growth. This review describes preclinical studies of omidenepag, published results of phase I-III clinical trials, and preliminary results of phase III trials currently in progress. Expert opinion: Omidenepag appears to provide IOP reductions comparable to those of prostaglandin F2α analogues, but without the cosmetic side effects common to prostaglandin F2α analogues, especially PAP syndrome. The lack of association between omidenepag and PAP suggests that longterm use of this agent may have advantages in patients with glaucoma.

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Clicking Eyelids: A New Finding of Prostaglandin-Associated Periorbitopathy

Cited by 7 publications

References 9 publications

Eyelash trichomegaly: a systematic review of acquired and congenital aetiologies of lengthened lashes

Eyelash trichomegaly: a systematic review of acquired and congenital aetiologies of lengthened lashes

Cockayne syndrome type 3 with dystonia‐ataxia and clicking blinks

Omidenepag isopropyl ophthalmic solution for open-angle glaucoma and ocular hypertension: an update

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