Click Evoked EEG Responses in Normal and Developmentally Retarded Infants

Barnet, Ann B.; Lodge, Ann

doi:10.1038/214252a0

Cited by 90 publications

(15 citation statements)

References 17 publications

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“…In this study performed on 16 subjects in each group and with the EP amplitudes evaluated by the standard deviation (reflecting a correct estimation of the N1P2 peak-to-peak amplitude; CaUaway, 1975), autistic children are significantly differentiated from both normal and mentally retarded children on the basis of smaller amplitudes. It must be noted that the result of large EP amplitudes recorded in retarded children are in agreement with literature data (Barnet & Lodge, 1967;Bigum, Dutsman, & Beck, 1970;Barnet, 1971;Straumanis, Shagass, & Overton, 1973;Yellin, Lodwig, & Jerison, 1980). The weak responses amplitudes observed in autistic children can be related to abnormalities in selective attention and responsiveness.…”

Section: Discussionsupporting

confidence: 82%

Auditory evoked responses and their modifications during conditioning paradigm in autistic children

Martineau

Garreau

Roux

et al. 1987

J Autism Dev Disord

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Auditory evoked responses (AERs) were recorded from 16 autistic children (ages 2-10 years) and age-matched normal and retarded controls. In order to test the ability to form auditory-visual cross-modal associations, often impaired in autism, the effects on AERs of coupling sound and light were studied with a paradigm that did not require the cooperation of the subject. Several differences between groups were found concerning the frequency and the amplitudes of present AERs. The pattern characterizing the effects on AERs of coupling sound and light (conditioning phenomenon) was observed for both autistic and normal controls, and not for retarded children. Results suggest that autistic children may have a real but slow learning ability.

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Section: Discussionsupporting

confidence: 82%

Auditory evoked responses and their modifications during conditioning paradigm in autistic children

Martineau

Garreau

Roux

et al. 1987

J Autism Dev Disord

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“…2). Studies in infants under 3 years have found an increase, rather than a decrease, in response amplitude with age (Barnet and Lodge, 1967;Ohlrich et al, 1978;Shucard et al, 1987) but have measured peak-to-peak amplitude from P 2 to N 2 . Several studies in which baseline-to-peak amplitude measurements were made have found disparate and complex results.…”

Section: Declining Response Magnitude Of P 1 and Nmentioning

confidence: 94%

Maturation of the cortical auditory evoked potential in infants and young children

2006

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“…DS children have also been shown to be slow to habituate to repeated stimuli. Event-and sensoryrelated potentials have been used to study this phenomenon for over 30 years (Barnet and Lodge, 1967;Dustman and Callner, 1979;Schafer and Peeke, 1982;Kaneko et al, 1996;Seidl et al, 1999). These findings are unique to DS and are not observable in all forms of mental retardation (Karrer et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Harm Avoidance, Anxiety, and Response to Novelty in the Adolescent S-100β Transgenic Mouse: Role of Serotonin and Relevance to Down Syndrome

Bell

Shokrian

Potenzieri

et al. 2003

Neuropsychopharmacol

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S-100b is an astroglial-derived protein, which plays a role in brain development and maintenance, and is known to play a specific role in the regulation of growth of the serotonergic neuronal system. In humans, the gene for S-100b is found on chromosome 21, within the region that is considered important for the phenotype of Down syndrome (DS). Thus, we have been studying a model of DS, the S-100b transgenic mouse. In the current study, we have examined anxiety and responses to novelty in adolescent (60-90 days) animals, at a time when we have shown the animals to be relatively lacking in serotonin innervation, compared to their CD-1 nontransgenic controls. In a test for approach/avoidance, the light/dark test, the S-100b transgenic mice animals showed no differences from control CD-1 mice. However, in the hole-board test for exploratory behavior, the S-100b animals were found to be less responsive to the inhibiting effects of the serotonin receptor 5-HT1A agonist, buspirone. Three tests were used to measure response to novelty. In the open field, the S100b animals showed greater activity longer than the control animals, and in the Y-maze test, the S-100b animals spent more time in the novel arm. In a test for novelty-induced gnawing, the S-100b animals were also more active than control animals. All of these suggest that the S-100b transgenic mice are slower to habituate to novelty than control animals. Finally, we tested the animals in a new procedure that we are proposing as a test for harm avoidance. In this apparatus, the S-100b animals showed more approaches to a novel and potentially harmful object than the control mice did. These results are discussed in reference to the known lack of serotonin in the animals, and to the behavioral phenotype of DS.

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Click Evoked EEG Responses in Normal and Developmentally Retarded Infants

Cited by 90 publications

References 17 publications

Auditory evoked responses and their modifications during conditioning paradigm in autistic children

Auditory evoked responses and their modifications during conditioning paradigm in autistic children

Maturation of the cortical auditory evoked potential in infants and young children

Harm Avoidance, Anxiety, and Response to Novelty in the Adolescent S-100β Transgenic Mouse: Role of Serotonin and Relevance to Down Syndrome

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