Cleavage of deoxyribonucleic acid by the 1,10-phenanthroline-cuprous complex. Hydrogen peroxide requirement and primary and secondary structure specificity

Dna Cleavage and Antimicrobial Activity Studies on Transition Metal(ii) Complexes of 4-Aminoantipyrine Derivative

“…The 1 H NMR spectrum of ligand (L) in CDCl 3 gives the following signals: phenyl as multiplet at 7.2-7.6 ppm, =C-CH 3 at 2.4 ppm, -N-CH 3 at 3.2 ppm and -CH=N-protons at 9.8 ppm. The peak at 13.2 ppm is attributable to the phenolic -OH group present in the salicylaldehyde.…”

“…Investigations of the interaction of DNA with small molecules are basic work in the design of new types of pharmaceutical molecules. Since the chemical nuclease activity of the copper-phenanthroline complex was discovered in 1980s, [1][2][3] studying the interaction model and the mechanism of transition metal complexes with DNA, and exploring the application of metal complexes in antineoplastic medication, molecular biology and bioengineering were hotspots in recent year. When some kinds of metal complexes interacted with DNA, they could induce the breakage of DNA strands by appropriate methods.…”

Dynamics and diversions in base excision DNA repair of oxidized abasic lesions

“…Ene-diyne drugs can also attack the C5' carbon to yield a strand break terminated by an oxidized 5'-aldehydic nucleotide, which retains the base (Dedon and Goldberg, 1992). Chemical oxidants such as Cu(II)-phenanthroline (Marshall et al, 1981;Meijler et al, 1997;Perrin et al, 1996;Pope et al, 1982;Zelenko et al, 1998) can generate C1'-derived OAS (dL and 3'-P), while H 2 O 2 in the presence of reduced iron or copper produces a range of OAS (and damaged bases) (Dizdaroglu et al, 2002). However, chemical agents often have low sequence selectivity, and their utility in studying the enzymology of BER for OAS is therefore more limited than drugs such as bleomycin.…”

Synthesis and Structural Properties of Copper(II), Nickel(II) and Cobalt(II) Complexes with 2,4-Furyliminobenzylacetophenone

“…This is further confirmed by its magnetic susceptibility value (3.85 BM). The electronic spectra of the nickel(II) complex exhibited [31][32][33] absorption bands at ∼16,670 and ∼27,780 cm −1 , attributable to 3 A 2g → 3 T 1g (F) and 3 A 2g → 3 T 1g (P), transitions, respectively, in an octahedral geometry.…”