Cleavage of Carbon—Carbon Single Bonds by Transition Metals

Investigation of C–C Bond Activation of sp–sp2 C–C Bonds of Acetylene Derivatives via Photolysis of Pt Complexes

“…Data for 2 are as follows. 1 Preparation of (dtbpe)Pt[η 2 -(CH 3 ) 3 CCCC(CH 3 ) 3 ] (3). Pt-(COD) 2 (10 mg, 0.024 mmol) was added to 1 mL of a C 6 D 6 solution of 2,2,5,5-tetramethyl-3-hexyne (3.4 mg, 0.024 mmol).…”

“…The solvents were available commercially and distilled from dark purple solutions of benzophenone ketyl. 1 H, 13 C{H}, and 31 P{ 1 H} NMR spectra were recorded on Bruker Avance-400 and Bruker Avance-500 spectrometers. All 1 H chemical shifts were referenced to residual proton resonances or to TMS in the deuterated solvents.…”

“Cut and Sew” Transformations via Transition-Metal-Catalyzed Carbon–Carbon Bond Activation

“…1 The activation of carbon–carbon single bonds has recently drawn particular attentions, 2 as one less reactive carbon–carbon bond can be converted into two more-reactive carbon–metal bonds leading to derivatization of each carbon terminus. Among various C–C activation-based transformations, the insertion of unsaturated moieties into a C–C single bond is of significant interest, because molecular complexity can be quickly built through uniting two fragments and reorganizing bond connections.…”

Copper‐Catalyzed Aerobic Oxidative Inert CC and CN Bond Cleavage: A New Strategy for the Synthesis of Tertiary Amides

“…Transition-metal-catalyzed selective unstrained CÀC bond cleavage, which enables the possibility of direct utilization of inert starting materials, has attracted much attention. [1,2] In recent years, numerous efficient catalytic systems, [3,4] such as arylation with halobenzenes, [5] amidation with formamide or amines (primary and secondary amines), [6] esterification with alcohols, [7] and others, [8] have been developed for the functionalization of inert CÀC bonds, which have contributed greatly to modern organic synthesis. The oxidative cleavage of CÀN bonds represents an important biochemical reaction and offers a major means for the detoxification of xenobiotics, [9] and is also of significant synthetic interest since such bonds are common in numerous molecules.…”