1994
DOI: 10.1001/archderm.130.12.1491
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Clearing of melanoma in situ with intralesional interferon alfa in a patient with xeroderma pigmentosum

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Cited by 7 publications
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“…However, in Western countries, there are reports on the usefulness of topical application of a liposome lotion containing prokaryotic DNA repair enzyme (bacteriophage T4 endonuclease V) and oral administration of 13‐cis‐retinoic acid in XP patients who cannot undergo radical operation because of poor general condition and the number of tumors, aiming at a suppressive effect on skin cancer development. It has been also reported that imiquimod is useful for actinic keratosis and basal cell carcinoma, and interferon‐α is useful for melanoma …”
Section: Treatment and Patient Carementioning
confidence: 99%
“…However, in Western countries, there are reports on the usefulness of topical application of a liposome lotion containing prokaryotic DNA repair enzyme (bacteriophage T4 endonuclease V) and oral administration of 13‐cis‐retinoic acid in XP patients who cannot undergo radical operation because of poor general condition and the number of tumors, aiming at a suppressive effect on skin cancer development. It has been also reported that imiquimod is useful for actinic keratosis and basal cell carcinoma, and interferon‐α is useful for melanoma …”
Section: Treatment and Patient Carementioning
confidence: 99%
“…Preliminary studies on the effectiveness of intralesional treatment of basal cell carcinoma have reported remission rates of up to 100 %[3, 5]. Results of primary treatment of in‐situ melanoma are also promising [6, 7]. In addition to their antimitotic effect on tumor cells, interferons have an immunomodulatory influence on nearby keratinocytes and tissue macrophages, stimulating synthesis of interleukin‐1 (IL‐1) and tumor necrosis factor‐α (TNF‐α) in particular.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to the surgical resection of skin tumors, local injection of skin neoplasms with interferon alpha may be useful for melanoma in situ [44]. …”
Section: Treatmentmentioning
confidence: 99%