volume 6, issue 1, P26-34 2014
DOI: 10.18632/aging.100631
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Fabio Marongiu, Maria Paola Serra, Marcella Sini, Fabrizio Angius, Ezio Laconi

Abstract: Increasing evidence indicates that carcinogenesis is dependent on the tissue context in which it occurs, implying that the latter can be a target for preventive or therapeutic strategies. We tested the possibility that re-normalizing a senescent, neoplastic-prone tissue microenvironment would exert a modulatory effect on the emergence of neoplastic disease. Rats were exposed to a protocol for the induction of hepatocellular carcinoma (HCC). Using an orthotopic and syngeneic system for cell transplantation, one…

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