1985
DOI: 10.1203/00006450-198510000-00019
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: ABSTRACT. Utilizing multicomponent spectrophotometry, we assayed the bilirubin content of rat cerebral hemispheres. With this assay, we determined the clearance of bilirubin from the rat brain following reversible, osmotic opening of the blood-brain barrier. Clearance was rapid, with a half-time of 1.7 h. This half-time was the same as that for clearance of bilirubin from the serum, suggesting that brain bilirubin was removed by transport or diffusion back into the general circulation. Hyperbilirubinemia is li… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
49
3
1

Year Published

1987
1987
2015
2015

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 64 publications
(55 citation statements)
references
References 15 publications
2
49
3
1
Order By: Relevance
“…In extremely low birth weight infants, kernicterus has been reported at TSB levels of 150 mol/L (8 mg/dL), ie, between commonly advised phototherapy and exchange transfusion thresholds. Several components of the pathogenesis of kernicterus indeed bear no relation to the serum bilirubin level: reversible opening of the blood brain barrier, 4,5 reserve binding capacity of albumin and total serum albumin level, 6,7 acidosis, 8 clearance of bilirubin from the brain, and duration of contact between free or bound bilirubin and brain endothelium. 1,9 In this report, we describe 5 instances of unexpected kernicterus in sick very low birth weight (VLBW) infants.…”
mentioning
confidence: 99%
“…In extremely low birth weight infants, kernicterus has been reported at TSB levels of 150 mol/L (8 mg/dL), ie, between commonly advised phototherapy and exchange transfusion thresholds. Several components of the pathogenesis of kernicterus indeed bear no relation to the serum bilirubin level: reversible opening of the blood brain barrier, 4,5 reserve binding capacity of albumin and total serum albumin level, 6,7 acidosis, 8 clearance of bilirubin from the brain, and duration of contact between free or bound bilirubin and brain endothelium. 1,9 In this report, we describe 5 instances of unexpected kernicterus in sick very low birth weight (VLBW) infants.…”
mentioning
confidence: 99%
“…Experimental allergic encephalomyelitis (EAE) represents an imperfect but valuable model for the study of multiple sclerosis (MS). EAE has been used extensively (1) for the study of immunological correllates of the inflammatory process and has provided significant data in the understanding of the underlying MRI pathological events seen in images of MS patients (2)(3)(4)(5)(6)(7). To this point a majority of the studies have been focussed on inflammation-dominated processes in the acute models.…”
Section: Discussionmentioning
confidence: 99%
“…For instance, the obstruction of bile flow causes an increase in bilirubin concentration in the liver and then in the blood, resulting in jaundice with yellow pigment visible in the eyes [11]. Furthermore, the increased amount of bilirubin can enter the brain through an opened blood-brain barrier, where it is differentially accumulated in the hippocampus and basal ganglia, with resultant neurotoxicity [17]. As newborn babies have an underdeveloped and hence highly permeable blood-brain barrier, they are especially vulnerable to this type of neurotoxicity.…”
Section: Pathogenesis Of Depression In Tcmmentioning
confidence: 99%
“…In brief, animals were orally administered TCM decoctions or their individual constituents for assessing their effectiveness in ameliorating depressive behavior. Studies found that Chaihu-Shugan-San and Bupleuri Radixcan ameliorate depression in a rat model of depression, as evidenced by an increase in sucrose consumption and a decreased immobility in the forced swimming test [17] [19] [20]. Saiko-Ka-Ryukotsu-Borei-To also increased riding time in a rotarod test in chronically stressed rats.…”
Section: Anti-depressant Effects Of Tcm Formulations and Chinese Herbsmentioning
confidence: 99%