Clear-cell squamous cell carcinoma: An uncommon variant of very common malignancy in the head and neck

Kakoti, Lopa Mudra; Mahanta, Debanwita; Sharma, Jagannath Dev; Chowdhury, Zachariah

doi:10.4103/ijohs.ijohs_23_18

Cited by 5 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its link to psoriasis is absent in the literature, and perhaps can be related to the chronic, degenerative changes in this skin disease. The literature suggests that these lesions present as rapidly growing, large exophytic masses, as in our patient 5…”

Section: Discussionsupporting

confidence: 64%

“…This case also warrants discussion because of its unique histopathology. Clear cell is an extremely rare variant of SCC associated with ultraviolet radiation 5 6. There are less than 10 cases reported in the literature, most commonly involving head and neck area 5–7.…”

Section: Discussionmentioning

confidence: 99%

“…Clear cell is an extremely rare variant of SCC associated with ultraviolet radiation 5 6. There are less than 10 cases reported in the literature, most commonly involving head and neck area 5–7. Clear cell refers to hydropic degeneration of neoplastic cell with accumulation of intracellular fluid showing characteristic histology 6.…”

Section: Discussionmentioning

confidence: 99%

“…Clear cell refers to hydropic degeneration of neoplastic cell with accumulation of intracellular fluid showing characteristic histology 6. The aetiology is uncertain, but factors such as chronic ulceration, radiation, immunosuppression and HPV oncogenesis, may be involved 5 6. Its link to psoriasis is absent in the literature, and perhaps can be related to the chronic, degenerative changes in this skin disease.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Split thickness skin graft in active psoriasis in patient with clear cell variant squamous cell carcinoma

Scupham¹,

Ingle

2019

BMJ Case Rep

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Split thickness skin graft in active psoriasis in patient with clear cell variant squamous cell carcinoma

Scupham¹,

Ingle

2019

BMJ Case Rep

View full text Add to dashboard Cite

show abstract

“…9 Different authors have suggested that "clear cell changes" could be a progressive process seen in advanced cases of OSCC, signifying its aggressive nature with possible early metastasis leading to poor prognosis. 5,10 This case report describes the case of a rare variant of OSCC as CCOSCC of the tongue with clinical and histopathology findings and literature review.…”

Section: Introductionmentioning

confidence: 99%

Clear cell variant of oral squamous cell carcinoma: case report and review

Mukkanwar¹,

Palaskar²,

Pawar³

et al. 2022

Autops Case Rep

View full text Add to dashboard Cite

The clear cell variant of Oral Squamous Cell Carcinoma (OSCC) is an uncommon histological variant. Kuo first discovered it in the skin, and Frazier et al. found it in the oral cavity. We know of only nine cases of clear cell variant of OSCC reported in the literature till now. The present case is in a 60-year-old male patient with an ulcer on the left posterolateral border of the tongue. The patient had a history of chewing tobacco for 22 years. Clinical examination showed features of malignant ulcer associated with pain and discomfort. Histopathological examination revealed sheets and islands of atypical epithelial cells with clear cytoplasm, nuclear and cellular pleomorphism, and few keratin pearls in the connective tissue suggesting OSCC. Various special stains were performed to identify clear cells. Periodic Acid Schiff-Diastase (PAS-D) and Mucicarmine stains showed positive and negative reactions in clear cells, respectively. Immunohistochemical (IHC) analysis for cytokeratin (AE1/AE3) showed diffuse positivity in clear cells and other epithelial cells. Based on special stains and IHC markers, we confirmed the diagnosis as a clear cell variant of OSCC. This variant is rare and presents diagnostic challenges. It is said to be aggressive in nature. More such cases should be reported to understand its biological behavior and prognosis.

show abstract

Clear Cell Squamous Cell Carcinoma of the Maxillary Gingiva Associated with PIK3CA and HRAS Mutations: Report of a Case and Literature Review

Hirose,

Shibahara,

Teramoto

et al. 2023

Head and Neck Pathol

View full text Add to dashboard Cite

Background Squamous cell carcinoma (SCC) is the most common oral malignancy, and somatic mutations in some driver genes have been implicated in SCC development. Clear cell SCC (CCSCC) is a rare histological variant of SCC, and various clear cell neoplasms must be considered in the differential diagnosis of CCSCC in the oral cavity. Based on a limited number of CCSCC cases reported in the oral cavity, CCSCC is considered an aggressive variant of SCC with a poor prognosis; however, its genetic characteristics remain unknown. Methods A maxillary gingival tumor in an 89-year-old female was described and investigated using immunohistochemical staining, special staining, fluorescence in situ hybridization, and next-generation sequencing (NGS) with a custom panel of driver genes, including those associated with SCC and clear cell neoplasm development. Results Histopathological examination revealed a proliferation of atypical epithelial cells with abundant clear cytoplasm and enlarged and centrally placed round nuclei. The tumor was exophytic with deep, penetrating proliferation. The atypical clear cells were continuous with the conventional SCC cells. Immunohistochemical analysis showed that the clear cells were positive for CK AE1/AE3 and CK5/6 and nuclear-positive for p63. In contrast, the clear cells were negative for αSMA, S100, HMB45, Melan-A, CD10, and p16. p53 immunoreactivity exhibited a wild-type expression pattern. Additionally, the clear cells were positive for periodic acid-Schiff (PAS) and negative for diastase-PAS, mucicarmine, and Alcian blue. Based on these results, the diagnosis of CCSCC was confirmed. Molecular analysis of the clear cells identified PIK3CA p.E542K (c.1624G>A) and HRAS p.G12A (c.35 G>C) somatic mutations classified as oncogenic. No pathogenic variants were identified in TP53, EWSR1, AKT1, PTEN, BRAF, KRAS, NRAS, RASA1, or MAML2. Conclusions We report a case of CCSCC of the oral cavity with PIK3CA and HRAS mutations. The identification of PIK3CA and/or HRAS mutations is rare in SCC; however, both mutations are important potential targets for antitumor therapy. A detailed analysis of gene mutations in CCSCC may lead to a better understanding of its biological behavior and an improved prognosis, as well as a differential diagnosis from other clear cell neoplasms.

show abstract

Clear-cell squamous cell carcinoma: An uncommon variant of very common malignancy in the head and neck

Cited by 5 publications

References 10 publications

Split thickness skin graft in active psoriasis in patient with clear cell variant squamous cell carcinoma

Split thickness skin graft in active psoriasis in patient with clear cell variant squamous cell carcinoma

Clear cell variant of oral squamous cell carcinoma: case report and review

Clear Cell Squamous Cell Carcinoma of the Maxillary Gingiva Associated with PIK3CA and HRAS Mutations: Report of a Case and Literature Review

Contact Info

Product

Resources

About