Clear Cell Adenocarcinoma of the Prostate: A Rare Oncologic Entity in a 42-Year-Old African American Man

Klaassen, Zachary; Cleveland, Curtis; McCraw, Casey O.; Burnette, Jason O.; Franken, Alicia A.; Wilhelm, Stephen; Kavuri, Sravan; Biddinger, Paul; Terris, Martha K.; Moses, Kelvin A.

doi:10.1016/j.urology.2014.06.042

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…Local recurrence in the pelvis was apparent 24 months after radical cystoprostatectomy in one patient and two patients died due to multi-organ failure (6 months after TURP and 29 months after radical cystoprostatectomy). 3,4,6 The treatment of RTCCC of the prostate is similar to that used to combat the more common forms of prostate cancer. [1][2][3][4]6 In the present case, bone scans revealed skeletal metastases at the inferior ramus of his bilateral pubic bone.…”

Section: Discussionmentioning

confidence: 99%

“…3,4,6 The treatment of RTCCC of the prostate is similar to that used to combat the more common forms of prostate cancer. [1][2][3][4]6 In the present case, bone scans revealed skeletal metastases at the inferior ramus of his bilateral pubic bone. After explaining the advantages and disadvantages of bilateral subcapsular orchiectomy and medical hormonal therapy, the patient chose the former, since the latter would require frequent trips to the outpatient department, which was problematic given how far he lives from the hospital and his limited access to transportation.…”

Section: Discussionmentioning

confidence: 99%

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Case Report: A rare case of renal-type clear cell carcinoma of the prostate

et al. 2021

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Renal-type clear cell carcinoma (RTCCC) of the prostate is a rare form of kidney cancer that is infrequently reported in the literature. Here we describe the case of an 81-year-old male patient with a hard, immovable mass on his enlarged prostate, which was discovered through a digital rectal examination. His prostate-specific antigen (PSA) level was 23.01 ng/ml, and bone multi-slice computed tomography scans revealed several osteoblastic lesions on the inferior ramus of his bilateral pubic bone. Tissue recovered during the trans urethral resection of the prostate was indicative of RTCCC with typical prostatic adenocarcinoma (Gleason score 3 + 4 = 7). Concerning treatment course, bilateral subcapsular orchiectomy was chosen over medical hormonal therapy. Upon follow-up 12 months post-surgery, his lower urinary tract symptoms were nearly resolved and his serum PSA level had decreased to 3.2 ng/ml. Accurate RTCCC diagnosis remains a pressing concern that warrants further investigation to optimize treatment selection and patient outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Case Report: A rare case of renal-type clear cell carcinoma of the prostate

et al. 2021

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“…Cases in males are even rarer still but have also been noted, such as a case of CCC of the prostate [6]. CCC of the upper urinary tract is extremely rare, with only 3 cases reported to the best of our knowledge.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Clear Cell Carcinoma, Müllerian Type in the Renal Pelvis of a 21-Year-Old Woman

Perez

2018

Case Reports in Pathology

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Clear Cell Carcinomas of Müllerian origin are extremely rare within the upper urinary system. Their morphology is identical to that of the Clear Cell Carcinomas of the female genital tract. When they arise in the urinary tract, it is thought to be due to ectopic Müllerian embryogenesis. Here, we present a case of a 21-year-old woman with a Clear Cell Carcinoma, Müllerian type, arising from the renal pelvis. Histologically, it consisted of tubulopapillary architecture with associated foamy macrophages and a mucinous background. The neoplastic cells exhibited variably sized round nuclei with prominent nucleoli, eosinophilic to vacuolated cytoplasm with occasional intracytoplasmic mucin vacuoles, and a hobnail appearance. Immunohistochemical stains showed that the neoplastic cells were positive for Pax-8, p53, CK7, HMWK 903, and INI-1 and focally positive for p504s (AMACR). The neoplastic cells were negative for GATA-3, CK5/CK6, p63, CK20, and CDX-2 immunostains, ruling out urothelial or enteric phenotype. Additional immunostains performed by an outside institution showed that the neoplastic cells were positive for HNF-1β. The overall morphology and immunophenotype were consistent with Clear Cell Carcinoma of Müllerian origin arising from the renal pelvis. Follow-up revealed no metastasis or other tumor sites, supporting that this was the primary location.

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“…Renal-type CCC of the prostate is extremely rare, but has been reported in recent years. 1 , 2 , 3 , 4 It is important to distinguish it from other CCCs of the male urinary tract, including metastatic RCC, a variant of PCa, UCC and adenocarcinoma of the urinary bladder, and mullerian CCC. 1 In the present case, the differential diagnosis was suggestive of them.…”

Section: Discussionmentioning

confidence: 99%

“…Clear cell carcinoma (CCC) of the prostate is a very rare condition, and information reported in the literature is limited. 1 , 2 , 3 , 4 Zinner syndrome is characterized by the triad of ipsilateral renal agenesis, seminal vesicle cyst, and ejaculatory duct obstruction. 5 Herein, we report a case of a 64-year-old man with Zinner syndrome who developed renal-type CCC of the prostate.…”

Section: Introductionmentioning

confidence: 99%

Renal-type Clear Cell Carcinoma Occurring in the Prostate With Zinner Syndrome

Sato

Kataoka

Hata

et al. 2016

Urology Case Reports

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We report a case of clear cell carcinoma occurring in the prostate with Zinner syndrome in a 64-year-old man. Based on the immunohistochemical findings, it was concluded that this tumor represented primary renal-type clear cell carcinoma arising in the prostate. After receiving radical cystoprostatectomy, he was treated with tyrosine kinase inhibitor (TKI) therapy for local recurrence in accordance with the protocol of renal cell carcinoma (RCC) treatment, because microarray cluster analysis using a resected sample demonstrated that the present case belonged to the cluster group of RCC.

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Clear Cell Adenocarcinoma of the Prostate: A Rare Oncologic Entity in a 42-Year-Old African American Man

Cited by 8 publications

References 9 publications

Case Report: A rare case of renal-type clear cell carcinoma of the prostate

Case Report: A rare case of renal-type clear cell carcinoma of the prostate

A Rare Case of Clear Cell Carcinoma, Müllerian Type in the Renal Pelvis of a 21-Year-Old Woman

Renal-type Clear Cell Carcinoma Occurring in the Prostate With Zinner Syndrome

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