2018
DOI: 10.18632/aging.101571
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Abstract: Calcium activated Chloride Channel A4 (CLCA4), as a tumor suppressor, was reported to contribute to the progression of several malignant tumors, yet little is known about the significance of CLCA4 in invasion and prognosis of hepatocellular carcinoma (HCC). CLCA4 expression was negatively correlated with tumor size, vascular invasion and TNM stage. Kaplan-Meier analysis showed that CLCA4 was an independent predictor for overall survival (OS) and time to recurrence (TTR). In addition, CLCA4 status could act as … Show more

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Cited by 23 publications
(28 citation statements)
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References 28 publications
(35 reference statements)
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“…For instance, EMT is reported to coordinate the occurrence of liver fibrosis, carcinogenesis, and proliferation and invasion of HCC cells ( Giannelli et al, 2016 ). The activation of PI3K/AKT signaling has been shown to promote EMT ( Liu et al, 2018 ). “Wnt/beta-catenin signaling”, “MYC target v1”, and “DNA repair” are closely related to tumorigenesis and the development of HCC ( Dolezal et al, 2017 ; Dimri and Satyanarayana, 2020 ; Pardini et al, 2020 ).…”
Section: Resultsmentioning
confidence: 99%
“…For instance, EMT is reported to coordinate the occurrence of liver fibrosis, carcinogenesis, and proliferation and invasion of HCC cells ( Giannelli et al, 2016 ). The activation of PI3K/AKT signaling has been shown to promote EMT ( Liu et al, 2018 ). “Wnt/beta-catenin signaling”, “MYC target v1”, and “DNA repair” are closely related to tumorigenesis and the development of HCC ( Dolezal et al, 2017 ; Dimri and Satyanarayana, 2020 ; Pardini et al, 2020 ).…”
Section: Resultsmentioning
confidence: 99%
“…Chen et al (2016b) demonstrated that loss of ZG16 was helpful for stemness and progression of CRC, which might provide a promising therapeutic strategy for advanced CRC. CLCA4 belonged to the calcium sensitive chloride conductance protein family and could act as a tumor suppressor in tumorigenesis and progression of several human cancers, including HCC, CRC, and bladder cancer (Hou et al, 2017;Liu et al, 2018;Chen et al, 2019). Recently, the development of a prognostic prediction model has become a research hotspot.…”
Section: Identification Of Genes Related To Clinicopathological Charamentioning
confidence: 99%
“…Research has demonstrated that CLCA protein members influence a wide range of biological processes, including cell differentiation, adhesion, apoptosis and airway inflammation (7)(8)(9). Recent studies have revealed that the expression levels of CLCA proteins, such as CLCA1, CLCA2 and CLCA4, are abnormal in a variety of cancer types (10)(11)(12)(13)(14)(15)(16), and could therefore be potential cancer predictors for patients. CLCA1 inhibits the proliferation of CRC cells and has been associated with a favorable prognosis of patients with CRC (10).…”
Section: Introductionmentioning
confidence: 99%