Clauemarazoles A–G, seven carbazole alkaloids from the stems of Clausena emarginata

Identification of Clausine E as an inhibitor of fat mass and obesity‐associated protein (FTO) demethylase activity

“…Carbazole alkaloids are an important class of nitrogen containing heterocycles present in many natural products and pharmaceutical ingredients . Phytochemical and pharmacological studies show that carbazole alkaloids have various bioactivities, such as anticancer activity, anti‐inflammation, antimicrobial, anti‐oxidation, and anti‐human immunodeficiency virus (HIV) effects . Micromeline, Clausine K, and some synthetic analogs exhibited antitubercular activity .…”

Hepatoprotective pyranocoumarins from the stems of Clausena emarginata

“…The previous study showed that the 95% ethanol extract displayed hepatoprotective activities against DL-galactosamine-induced damage in WB-F344 cells in vitro. Recently, the isolation and identification of twelve new A,D-seco-limonoids, two new amide alkaloids, and seven new carbazole alkaloids from the 95% ethanol extract of the stems of this plant was reported (Xia et al, 2014a;2014b;2015). As a part of this ongoing research program for bioactive metabolites contributing to hepatoprotective activity, seven new pyranocoumarins, clauemarmarins AÀG (1e7), as well as six known compounds (8e13) (Fig.…”

Bioactive Coumarins from the Stems of Clausena emarginata

“…Our research group has previously characterized a variety of bioactive carbazole alkaloids and limonoids from C . emarginata . As a part of our ongoing research for the bioactive constituents of the stems of C. emarginata systematically, a detailed phytochemical investigation on the 95% EtOH extract of this plant led to the isolation of five new coumarins, clauemarmarins I – M, together with 10 known analogs ( Fig.…”