volume 9, issue 4, P356-362 2008
DOI: 10.1038/embor.2008.28
View full text
|
Sign up to set email alerts
|
Share

Abstract: There are several endocytic pathways, which are either dependent on or independent of clathrin. This study focuses on a poorly characterized mechanism-clathrin-and caveolae-independent endocytosis-used by the interleukin-2 receptor b (IL-2Rb). We address the question of its regulation in comparison with the clathrin-dependent pathway. First, we show that Ras-related C3 botulinum toxin substrate 1 (Rac1) is specifically required for IL-2Rb entry, and we identify p21-activated kinases (Paks) as downstream targe…

Expand abstract