Classification of Parathyroid Cancer

Schulte, Klaus–Martin; Gill, Anthony J.; Barczyński, Marcin; Karakas, Elias; Miyauchi, Akira; Knoefel, W. T.; Lombardi, Celestino Pio; Talat, Nadia; Díaz‐Cano, Salvador; Grant, Clive S.

doi:10.1245/s10434-012-2306-6

Cited by 63 publications

(49 citation statements)

References 28 publications

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“…The low-risk group was stratified based on the finding of an infiltrative growth pattern with capsular invasion and surrounding soft tissue invasion. The high-risk group showed evidence of vascular invasion with or without invasion of vital organs or distant metastases [74]. The highrisk group had a 12.8 times higher rate of recurrence and a considerably lower 5-year disease-free survival compared to the low-risk group.…”

Section: Stagingmentioning

confidence: 88%

Current Understanding and Management of Parathyroid Carcinoma

Arrangoiz¹

2017

JCTR

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Parathyroid adenomas are a very common endocrine entity, whereas parathyroid carcinomas (PC) are extremely rare. With an estimated incidence of 0.015 per 100,000 population and an estimated prevalence of 0.005% in the United States, parathyroid cancer is one of the rarest of all human malignancies. PC is an extremely rare cause of primary hyperparathyroidism (PHPT). Men and women are equally affected, usually in the fourth or fifth decade of life. The exact etiology has not been identified, but mutations in the CDC73 gene appear to have a critical role in its pathogenesis. The morbidity and mortality of PC is secondary to the hypercalcemia resulting from tumor overproduction of PTH. The primary management objectives are complete removal of the cancer and prevention of recurrences. This review will talk about the epidemiology, etiology, clinical manifestations, and management of PC.

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Section: Stagingmentioning

confidence: 88%

Current Understanding and Management of Parathyroid Carcinoma

Arrangoiz¹

2017

JCTR

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“…The only classification criteria are those proposed by Schulte et al, in which the cut-off between low-risk and high-risk cancers is defined from the lymph node metastases and the involvement of the major anatomical neck structures, such as trachea, oesophagus and major neck vessels (26). Although several diagnostic exams have been proposed for the diagnosis of the PC, neck ultrasound is the most reliable for the initial diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Long-term follow-up and information on mortality are not available, but the advanced stage of the PC at diagnosis likely predict a poor prognosis, worse than that of patients with classical hypercalcemic PC (2,7,9,(49)(50)(51)(52)(53). In the present case, we preferred to perform a thyroid lobectomy because of the pre-existent ipsi-lateral vocal fold paralysis and for taking the opportunity of avoiding the possible sequelae and complications of the total thyroidectomy (57)(58)(59)).…”

Section: © C I C E D I Z I O N I I N T E R N a Z I O N A L Imentioning

confidence: 99%

Non-functioning parathyroid cystic tumour: malignant or not? Report of a case

Cocorullo¹,

Scerrino²,

Melfa³

et al. 2017

GHIR

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“…Schulte reported that the low-risk (invasion limited to the capsule and soft tissue) versus high-risk (vascular invasion, lymph node metastasis or invasion of the trachea, esophagus or major cervical vessels) classification was an excellent predictor of disease-specific mortality and recurrence in a multicenter validation study on parathyroid carcinoma. 41 Using the information provided by various reviews on parathyroid carcinoma, Shaha and Shah proposed a staging system based on the size of the tumor, extent of local invasion, and presence of regional nodal disease and distant metastasis. 42 Ultrasonography, radionuclide scanning, computed tomography (CT) and magnetic resonance imaging (MRI) have been used for the initial diagnosis and the detection of recurrence in patients with parathyroid carcinoma.…”

Section: Discussionmentioning

confidence: 99%