Classification de l’OMS 2017 des tumeurs de la tête et du cou : principales nouveautés et mise à jour des méthodes diagnostiques

Sarradin, Victor; Siegfried, Aurore; Uro‐Coste, Emmanuelle; Delord, Jean‐Pierre

doi:10.1016/j.bulcan.2018.04.004

Cited by 40 publications

(22 citation statements)

References 24 publications

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“…This presence of the different classification systems, together with the inherent subjectivity of some histological parameters, caused great inter-examiner variability and a lack of standardization in the diagnosis of epithelial dysplasia [ 26 ], which, in our opinion, should be corrected. In this sense, the search for altered morphological patterns that can be detected by mechanized and standardized reproducible methods, other than the human eye, could be of great help in diagnosis [ 27 , 28 , 29 , 30 ]. Many studies have been carried out, trying to find quantifiable signs that could help us to evaluate the malignant capacity of OLs.…”

Section: Discussionmentioning

confidence: 99%

Use of the Fractal Dimension to Differentiate Epithelium and Connective Tissue in Oral Leukoplakias

Sánchez

García

Chamorro-Petronacci

et al. 2022

Cancers

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Background: Oral leukoplakia (OL) is considered one of the most common potentially malignant oral disorders (OPMD), with a verified increased risk of developing oral cancer. The identification of the dysplasia grade (low–high) is the only consolidated factor used to evaluate this risk. The objective of this study was to verify the role of the fractal dimension (FD) in assessing this dysplasia. Methods: To begin, 29 OL and 10 normal oral mucosa (NOM) biopsies were retrieved for FD analysis of the epithelial (dime) and the connective (dimc) tissue. Results: In the OL group, the median value of dime is higher (1.67, IQR = 0.12) than for the NOM group (1.56, IQR = 0.08), with statistically significant differences (Wilcoxon test, p = 0.0031). There were no differences in relation to dimc. Significant differences were observed between the non-dysplasia vs. high-grade (p = 0.0156) and low-grade vs. high-grade (p = 0.0049) groups. No significant differences were identified in relation to dimc for the different degrees of dysplasia. For a cut-off point of 1.44 of dime, a specificity of 96.6% was obtained, a sensitivity of 100%, and an AUC = 0.819 (p = 0.003). Conclusions: FD at the level of the epithelium may be used as a diagnostic tool in OL.

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Section: Discussionmentioning

confidence: 99%

Use of the Fractal Dimension to Differentiate Epithelium and Connective Tissue in Oral Leukoplakias

Sánchez

García

Chamorro-Petronacci

et al. 2022

Cancers

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“…2 According to the World Health Organization (WHO) classification, there are different subtypes of SGT with different molecular and prognostic implications. 3 Additionally, SGT encompass a heterogeneous group of diseases arising from different locations including major salivary glands (parotid, submandibular, and sublingual) and minor salivary glands. 4 Overall, the prognosis of patients with recurrent inoperable or metastatic SGT remains limited.…”

Section: Introductionmentioning

confidence: 99%

Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS‐001 clinical trial

Hernando‐Calvo,

Malone,

Day

et al. 2023

Cancer Medicine

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ObjectivesWe aimed to evaluate the activity of selinexor, an oral selective inhibitor of nuclear export, in patients with recurrent or metastatic salivary gland tumors (SGT).MethodsGEMS‐001 is an open‐label Phase 2 study for patients with recurrent or metastatic SGT with two parts. In Part 1 of the protocol, patients had tumor samples profiled with targeted next generation sequencing as well as immunohistochemistry for androgen receptor, HER‐2 and ALK. For Part 2, patients with no targeted therapies available were eligible to receive selinexor 60 mg given twice weekly every 28 days. The primary endpoint was objective response rate. Secondary endpoints included progression‐free survival (PFS) and prevalence of druggable alterations across SGT.ResultsOne hundred patients were enrolled in GEMS‐001 and underwent genomic and immunohistochemistry profiling. A total of 21 patients who lacked available matched therapies were treated with selinexor. SGT subtypes (WHO classification) included adenoid cystic carcinoma (n = 10), salivary duct carcinoma (n = 3), acinic cell carcinoma (n = 2), myoepithelial carcinoma (n = 2), carcinoma ex pleomorphic adenoma (n = 2) and other (n = 2). Of 18 evaluable patients, stable disease (SD) was observed in 17 patients (94%) (SD ≥6 months in 7 patients (39%)). However, no objective responses were observed. The median PFS was 4.9 months (95% confidence interval, 3.4–10). The most common treatment‐related Grade 1–2 adverse events were nausea [17 patients (81%)], fatigue [16 patients (76%)], and dysgeusia [12 patients (57%)]. Most common treatment‐related Grade 3–4 adverse events were hyponatremia [3 patients (14%)], neutrophil count decrease [3 patients (14%)] and cataracts [2 patients (10%)]. No treatment‐related deaths were observed.ConclusionsAlthough tumor reduction was observed across participants, single agent selinexor anti‐tumor activity was limited.

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“…ВОЗ относит к потенциально злокачественным расстройствам полости рта: лейкоплакию, эритроплакию, эритролейкоплакию, оральный субмукозный фиброз, врождённый дискератоз, кератоз от бездымного табака, поражения нёба при реверсном курении (зажжённый конец сигареты в полости рта), хронический кандидоз, красный плоский лишай, дискоидную красную волчанку, сифилитический глоссит, актинический кератоз (только губ) [7,8].…”

Section: Introductionunclassified

The influence of subject learning on the skills of decoding autofluorescent images of the oral mucosa

Рыхлевич¹,

Сандаков²,

Кочубей³

et al. 2021

Acta biomedica scientifica

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Background. Despite the ease of implementation, harmlessness, painlessness and speed of the study, the method of autofluorescence does not belong to the routine and often used because of the dependence on the skill of the dentist in interpretation of the resulting visualization. Foreign and domestic researchers speak about the need for thematic training of dentists for the widespread introduction of the autofluorescence method into practice. There is no data proving the influence of training on the skill of interpretation autofluorescence images and showing the dependence of the skill on the duration of training and its frequency.The aim of the study was to conduct a comparative analysis of the results of interpreting autofluorescence images of the oral mucosa by dentists before and after thematic training.Methods. 308 dentists interpreted 20 images of autofluorescence of the oral mucosa before and after the thematic training, 10 of them were of potentially malignant diseases of the oral mucosa, 10 – of benign lesions and paraphysiological anomalies. Correctly identified mucosal changes presented in the autofluorescence image were considered positive results of decoding. The results were evaluated relative to the duration of training and its frequency, taking into account the duration of breaks, according to the average number of positive results.Results. Before the thematic training, dentists on average decoded 8.41 ± 4.89 images, after training – 12.11 ± 3.12 images. The difference before and after the thematic training between the number of positive results of interpretation autofluorescence images is statistically significant (t = –14.1, p˂ 0.001). There was no significant difference in the results of interpretation potentially malignant oral diseases (F = 1.67; p = 0.190) and benign lesions and conditions (F = 0.647; p = 0.524) between the three groups that studied for 6, 12 and 18 hours. There is a correlation to the duration of the interruption of training with positive results of decoding (r = –0.3376; p˂ 0.001). The positive results of interpretation of autofluorescence with regular monthly 6-hour training had significant increasing trends (12.11 ± 3.12 and 13.22 ± 1.76, t = –3.41, p = 0.001; 13.22 ± 1.76 and 14.40 ± 1.81, t = –4.74, p˂ 0.001).Conclusion. Thematic training improves the skill of interpretation autofluorescence images in dentists. The regularity of short-term training is more important for maintaining the interpretation skill than the duration of training.

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Classification de l’OMS 2017 des tumeurs de la tête et du cou : principales nouveautés et mise à jour des méthodes diagnostiques

Cited by 40 publications

References 24 publications

Use of the Fractal Dimension to Differentiate Epithelium and Connective Tissue in Oral Leukoplakias

Use of the Fractal Dimension to Differentiate Epithelium and Connective Tissue in Oral Leukoplakias

Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS‐001 clinical trial

The influence of subject learning on the skills of decoding autofluorescent images of the oral mucosa

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