Class III receptor tyrosine kinases: role in leukaemogenesis

FLT3 mutations in acute myeloid leukemia cell lines

“…FL induces growth of many AML cells, suggesting that FLT3 signalling is important not only for normal hematopoiesis but also for the proliferation of leukemic cells. 30 Recently, it has been demonstrated that short duplications of the juxtamembrane part of FLT3 lead to the constitutive activation of the receptor and confer a persisting growth stimulus to the cells. 13,14 ITD occur in about 20% of AML cases, [7][8][9][10][11] and the affected patients have a decreased chance of cure.…”

Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples

“…Activating mutations of RTKs result in ligand-independent signals for cell growth. 3 Among the class III RTKs, FLT3 mutations have been intensively studied in childhood AML. [4][5][6][7][8] The frequencies of c-KIT mutations in childhood CBF-AML varied considerably.…”

“…FLT3, c-KIT and CSF1R belong to class III receptor tyrosine kinases (RTKs) and play a crucial role in hematopoiesis. 3 Ligand binding to RTKs induces receptor dimerization and autophosphorylation. Activating mutations of RTKs result in ligand-independent signals for cell growth.…”

FLT3: ITDoes matter in leukemia

“…1 Deregulated tyrosine kinase activity has long been implicated in the molecular pathogenesis of cancer, including leukemia, and mutant forms of KIT, ABL, and platelet-derived growth factor receptor (PDGF-R) number among the constitutively activated tyrosine kinases that have been identified as causative factors in specific hematologic malignancies. [2][3][4] FMS-like tyrosine kinase-3 (FLT3), a member of the PDGF-R subfamily of receptor tyrosine kinases, is the most recent major addition to this list. [5][6][7] Acute leukemia is thought to arise from leukemic stem cells, the properties of which have only recently begun to be characterized.…”