Clarithromycin: a new perspective in rosacea treatment

Torresani, Claudio

doi:10.1046/j.1365-4362.1998.00442.x

Cited by 17 publications

(12 citation statements)

References 6 publications

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“…Azithromycin may also be the preferable agent for those taking other medications, because it has no major drug interactions 4 . Incidence of gastrointestinal side‐effects compared with erythromycin was reported to be lower (9.5% vs. 20.6%) 14 . It was well tolerated by our patients, except in one patient in whom treatment was withheld because of diarrhea.…”

Section: Discussionmentioning

confidence: 68%

Therapeutic potential of azithromycin in rosacea

2004

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Section: Discussionmentioning

confidence: 68%

Therapeutic potential of azithromycin in rosacea

2004

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“…As second‐generation macrolides, clarithromycin and azithromycin take effect faster and are better tolerated with regard to gastrointestinal side effects than orally administered tetracyclines, metronidazole and ketoconazole 52 . In several smaller studies, both have been found to be effective and tolerable drugs in the short‐term therapy of rosacea 52–54 . After a 12‐week treatment with azithromycin in decreasing doses, there was a 75% decrease in total scores and an 89% decrease in inflammatory lesion scores compared with basal values 54 .…”

Section: Macrolidesmentioning

confidence: 99%

Current topical and systemic approaches to treatment of rosacea

Hc¹,

Schöllmann

2009

Acad Dermatol Venereol

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Rosacea is a common, often overlooked, chronic facial dermatosis characterized by intermittent periods of exacerbation and remission. Clinical subtypes and grading of the disease have been defined in the literature. On the basis of a genetic predisposition, there are several intrinsic and extrinsic factors possibly correlating with the phenotypic expression of the disease. Although rosacea cannot be cured, there are several recommended treatment strategies appropriate to control the corresponding symptoms/signs. In addition to adequate skin care, these include topical and systemic medications particularly suitable for the papulopustular subtype of rosacea with moderate to severe intensity. The most commonly used and most established therapeutic regimens are topical metronidazole and topical azelaic acid as well as oral doxycycline. Conventionally, 100-200 mg per day have been used. Today also a controlled release formulation is available, delivering 40 mg per day using non-antibiotic, anti-inflammatory activities of the drug. Anti-inflammatory dose doxycycline in particular allows for a safe and effective short-and long-term therapy of rosacea. Topical metronidazole and topical azelaic acid also appear to be safe and effective for short-term use. There are indications that a combined therapy of anti-inflammatory dose doxycycline and topical metronidazole could possibly have synergy effects. Further interesting therapy options for the short-and long-term therapy of rosacea could be low-dose minocycline and isotretinoin; however, too little data are available with regard to the effectiveness, safety, optimal dosage and appropriate length of treatment for these medications to draw final conclusions.

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“…Additionally, azithromycin shows lower incidences of gastrointestinal discomfort compared with erythromycin (16). According to one clinical study, only two of 32 patients complained of mild gastric discomfort and no one withdrew from the study due to the side-effects of aztithromycin (17).…”

Section: Discussionmentioning

confidence: 99%

Oral Azithromycin for Treatment of Intractable Rosacea

Kim

Choi

2011

J Korean Med Sci

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Rosacea is a common chronic cutaneous disorder that primarily occurs on the convex surfaces of the central face and is often characterized by exacerbations and remissions. A case of a 52-yr-old woman visited our clinic in February 2008 complaining typical features of rosacea including multiple pinhead to rice-sized erythematous papules. We applied various conventional treatments including topical benzoyl peroxide and metronidazole as well as oral metronidazole, isotretinoin, and doxycycline. The lesions were not controlled but were rather aggravated by complications from these treatments. Therefore, we prescribed oral azithromycin, which has anti-inflammatory effects and reduces reactive oxygen species. Ten weeks after the administration of oral azithromycin, 500 mg per day for 2 weeks, the lesions had mostly disappeared and no specific side effects related to the azithromycin were noted. Oral azithromycin dosing 500 mg/day for 2 weeks is effective for treatment of intractable rosacea.

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Clarithromycin: a new perspective in rosacea treatment

Cited by 17 publications

References 6 publications

Therapeutic potential of azithromycin in rosacea

Therapeutic potential of azithromycin in rosacea

Current topical and systemic approaches to treatment of rosacea

Oral Azithromycin for Treatment of Intractable Rosacea

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