Citrinin mycotoxicosis in the rabbit

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

“…Similar results have been reported by Jordan et al [475,476] and Phillips et al [477]. Damage of the proximal tubules (brush border disruption, cytoplasmic rarefaction, swelling of interdigitating processes, condensed mitochondria, azotemia, metabolic acidosis and hypokaliema, glycosuria, increased blood urea nitrogen and serum creatine but decrease of creatinine clearance) were obtained at CIT doses of 67 and 130 mg/kg bw in rabbits [478][479][480]. CITinduced damages of proximal tubules were also obtained in various birds (turkey, ducklings, white leghorns, chicks [48,482]).…”

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

“…Similar results have been reported by Jordan et al [475,476] and Phillips et al [477]. Damage of the proximal tubules (brush border disruption, cytoplasmic rarefaction, swelling of interdigitating processes, condensed mitochondria, azotemia, metabolic acidosis and hypokaliema, glycosuria, increased blood urea nitrogen and serum creatine but decrease of creatinine clearance) were obtained at CIT doses of 67 and 130 mg/kg bw in rabbits [478][479][480]. CITinduced damages of proximal tubules were also obtained in various birds (turkey, ducklings, white leghorns, chicks [48,482]).…”

Mycotoxins Affecting the Kidney

“…Despite this, the specific pathologies resulting from acute citrinin exposure are remarkably similar in all species. Initial pathological observations report the kidneys of acutely exposed mice to be swollen and pale, with stippling of the capsule cortex and outer medulla (Jordan and Carlton, 1977;Hanika and Carlton, 1983). Similar findings have been reported for other tested species (Hanika and Carlton, 1983;Jordan and Carlton, 1978;Jordan et al, 1978b).…”

Nutrition and feeding strategy: impacts on health status.

“…Citrinin is found in mouldy cereals contaminated by various fungal species of Aspergillus and Penicillium. Ingestion of this toxin induces acute erosive gastritis and fluid diarrhoea, with some rabbits dying less than 24 h after oral administration of a single 100-130 mg kg −1 body weight dose (Hanika et al, 1983). In the rabbit, citrinin also causes renal damage with tubular dysfunction and necrosis similar to that found in other animal species (Hanika et al, 1984).…”

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

“…Similar results have been reported by Jordan et al [475,476] and Phillips et al [477]. Damage of the proximal tubules (brush border disruption, cytoplasmic rarefaction, swelling of interdigitating processes, condensed mitochondria, azotemia, metabolic acidosis and hypokaliema, glycosuria, increased blood urea nitrogen and serum creatine but decrease of creatinine clearance) were obtained at CIT doses of 67 and 130 mg/kg bw in rabbits [478][479][480]. CITinduced damages of proximal tubules were also obtained in various birds (turkey, ducklings, white leghorns, chicks [48,482]).…”

Mycotoxins Affecting the Kidney

“…Despite this, the specific pathologies resulting from acute citrinin exposure are remarkably similar in all species. Initial pathological observations report the kidneys of acutely exposed mice to be swollen and pale, with stippling of the capsule cortex and outer medulla (Jordan and Carlton, 1977;Hanika and Carlton, 1983). Similar findings have been reported for other tested species (Hanika and Carlton, 1983;Jordan and Carlton, 1978;Jordan et al, 1978b).…”

Nutrition and feeding strategy: impacts on health status.

“…Citrinin is found in mouldy cereals contaminated by various fungal species of Aspergillus and Penicillium. Ingestion of this toxin induces acute erosive gastritis and fluid diarrhoea, with some rabbits dying less than 24 h after oral administration of a single 100-130 mg kg −1 body weight dose (Hanika et al, 1983). In the rabbit, citrinin also causes renal damage with tubular dysfunction and necrosis similar to that found in other animal species (Hanika et al, 1984).…”

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

“…Similar results have been reported by Jordan et al [475,476] and Phillips et al [477]. Damage of the proximal tubules (brush border disruption, cytoplasmic rarefaction, swelling of interdigitating processes, condensed mitochondria, azotemia, metabolic acidosis and hypokaliema, glycosuria, increased blood urea nitrogen and serum creatine but decrease of creatinine clearance) were obtained at CIT doses of 67 and 130 mg/kg bw in rabbits [478][479][480]. CITinduced damages of proximal tubules were also obtained in various birds (turkey, ducklings, white leghorns, chicks [48,482]).…”

Mycotoxins Affecting the Kidney

“…Despite this, the specific pathologies resulting from acute citrinin exposure are remarkably similar in all species. Initial pathological observations report the kidneys of acutely exposed mice to be swollen and pale, with stippling of the capsule cortex and outer medulla (Jordan and Carlton, 1977;Hanika and Carlton, 1983). Similar findings have been reported for other tested species (Hanika and Carlton, 1983;Jordan and Carlton, 1978;Jordan et al, 1978b).…”

Nutrition and feeding strategy: impacts on health status.

“…Citrinin is found in mouldy cereals contaminated by various fungal species of Aspergillus and Penicillium. Ingestion of this toxin induces acute erosive gastritis and fluid diarrhoea, with some rabbits dying less than 24 h after oral administration of a single 100-130 mg kg −1 body weight dose (Hanika et al, 1983). In the rabbit, citrinin also causes renal damage with tubular dysfunction and necrosis similar to that found in other animal species (Hanika et al, 1984).…”