2015
DOI: 10.1016/j.circir.2015.04.003 View full text |Buy / Rent full text
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Abstract: Pro-- inflammatory serum cytokine levels were higher in the diabetes mellitus with diabetic retinopathy group. Larger studies are warranted to establish the real impact of this finding.

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“…These result in arteriosclerosis and microthrombosis, and eventually lead to DR. [ 2 ] Inflammatory cytokines play an important role in DR, but the detailed mechanism remains unclear. [ 3 ] The study conducted by Canning et al [ 4 ] revealed that lipoprotein-associated phospholipase A2 (Lp-PLA2) and its main enzyme-promoting production lysophosphatidylcholine (LPC) were closely related to damage induced to the blood-retinal barrier in DR, and that LPC could influence vascular permeability, and thereby impair the function of retinal vascular endothelial cells through VEGF receptor 2. There are no clinically effective drugs for preventing DR and the progression of nonproliferative diabetic retinopathy (NPDR) into diabetic proliferative retinopathy (PDR), except for the management of blood glucose, blood lipids, blood pressure, and other risk factors.…”
Section: Introductionmentioning
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“…These result in arteriosclerosis and microthrombosis, and eventually lead to DR. [ 2 ] Inflammatory cytokines play an important role in DR, but the detailed mechanism remains unclear. [ 3 ] The study conducted by Canning et al [ 4 ] revealed that lipoprotein-associated phospholipase A2 (Lp-PLA2) and its main enzyme-promoting production lysophosphatidylcholine (LPC) were closely related to damage induced to the blood-retinal barrier in DR, and that LPC could influence vascular permeability, and thereby impair the function of retinal vascular endothelial cells through VEGF receptor 2. There are no clinically effective drugs for preventing DR and the progression of nonproliferative diabetic retinopathy (NPDR) into diabetic proliferative retinopathy (PDR), except for the management of blood glucose, blood lipids, blood pressure, and other risk factors.…”
Section: Introductionmentioning