Citalopram for pediatric functional abdominal pain: a randomized, placebo‐controlled trial

Roohafza, Hamidreza; Pourmoghaddas, Zahra; Saneian, Hossein; Gholamrezaei, Ali

doi:10.1111/nmo.12444

Cited by 54 publications

(38 citation statements)

References 25 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No therapeutic action of mebevirin and citalopram 24 was found in the FAP treatment 25 . Regarding the dietary approach 23 , there were no satisfactory results with probiotics or symbiotics in the FAP treatment 24 .…”

Section: Category 4 Treatment and Intervention Strategies For The Fumentioning

confidence: 88%

See 1 more Smart Citation

Functional abdominal pain: an integrative review study from a biopsychosocial view

Silva

Speridião

Zihlmann

2018

Brazilian Journal of Pain

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVES:Abdominal pain is one of the most frequent complaints in Pediatric Gastroenterology and may be considered an intricate symptom difficult of immediate differential diagnosis. To perform an integrative review of functional abdominal pain in children. CONTENTS: It included original and empirical national and international articles, between 2006 and 2016, from the Virtual Health Library, Virtual Health Library -Psychology Brazil (BVS-Psi Brazil) and Pubmed databases, in children aged 6 to 10 years old. The descriptors were: functional abdominal pain, children, gastroenterology. The thematic content was analyzed in the categories: etiology, prevalence, diagnosis process, treatment and intervention strategies and evaluation of coping strategies. Thirty-three articles on functional abdominal pain were found. Factors associated with somatization, anxiety, depression and children's bowel habits were highlighted and should be carefully evaluated by health professionals. Parents may negatively influence the treatment when they adopt encouraging, monitoring, and hypervigilance attitudes. CONCLUSION: Behavioral, dietary and pharmacological approaches are widely recommended in the treatment of functional abdominal pain. Regarding the emotional behavior, the psychological approach seems to promote good therapeutic results. RESUMO JUSTIFICATIVA E OBJETIVOS:A dor abdominal é uma das queixas mais frequentes em Gastroenterologia Pediátrica, podendo ser considerada um sintoma intrincado com dificuldade do diagnóstico diferencial imediato. Realizar revisão integrativa sobre dor abdominal funcional em crianças. CONTEÚDO: Incluiu artigos originais e empíricos nacionais e internacionais, entre 2006 e 2016, nas bases de dados Biblioteca Virtual de Saúde, Biblioteca Virtual em Saúde -Psicologia Brasil (BVS-Psi Brasil) e Pubmed, em crianças entre 6 e 10 anos. Os descritores foram: dor abdominal funcional, criança, gastroenterologia. A temática foi analisada nas categorias: etiologia, prevalência, processo de diagnóstico, estratégias de tratamento e avaliação das estratégias de enfrentamento. Foram encontrados 33 artigos sobre dor abdominal funcional. Destacou-se fatores associados à somatização, ansiedade, depressão e hábitos evacuatórios das crianças, que devem ser cuidadosamente avaliados pelos profissionais de saúde. Os pais podem influenciar negativamente o tratamento quando adotam atitudes de encorajamento, monitoramento e hipervigilância. CONCLUSÃO: Abordagens terapêuticas do tipo comportamental, dietética e farmacológica, são amplamente recomendadas no tratamento da dor abdominal funcional. Na vigência de comemorativos do comportamento emocional, a abordagem psicológica parece promover bons resultados terapêuticos. Descritores: Criança, Dor abdominal, Gastroenterologia, Revisão integrativa. Functional abdominal pain: an integrative review study from a biopsychosocial view Br J Pain. São Paulo, 2018 oct-dec;1(4):359-64 Functional abdominal pain: an integrative review study from a biopsychosocial view Br J Pa...

show abstract

Section: Category 4 Treatment and Intervention Strategies For The Fumentioning

confidence: 88%

“…Zimmerman et al 18 Transversal 3 Pourmoghaddas et al 24 Placebo-controlled clinical trial 4 Roohafza et al 25 Placebo-controlled clinical trial 4 Rutten, Benninga, and Vlieger 19…”

Section: Prospective Longitudinalmentioning

confidence: 99%

Functional abdominal pain: an integrative review study from a biopsychosocial view

Silva

Speridião

Zihlmann

2018

Brazilian Journal of Pain

View full text Add to dashboard Cite

show abstract

“…93 Similarly, results in a pediatric trial on functional abdominal pain did not support efficacy. 94 Most studies examined SSRI therapy in IBS with several suggesting benefit, [95][96][97] whereas others could not demonstrate superiority over placebo, especially if patients with coexisting depression were excluded from the trials. 98,99 Although preclinical experiments suggest a potentiating effect of SSRI on morphine effects, current evidence does not support their use as adjuncts in pain management.…”

Section: Treatmentmentioning

confidence: 99%

Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD

Thorkelson

Bielefeldt

Szigethy

2016

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

Antidepressant medications are frequently prescribed for depression, anxiety disorders, and chronic pain syndromes, but overall support for their efficacy is modest at best. Psychological interventions have growing support for having much more robust effects without the side effects of antidepressants and should be considered first-line treatment or at least an adjunct to psychotropic medications for these conditions.

show abstract

“…Citalopram (Celexa™, Cipramil™) is administered in 10-80 mg dose once daily for the treatment of depression ( Table 3). It has been investigated for the treatment of fibromyalgia and chronic tension-type headache, with no beneficial results [47][48][49], while for somatoform pain disorders it has only moderate analgesic effect [50][51][52].…”

Section: Citaloprammentioning

confidence: 99%

Serotonin Reuptake Inhibitors and Their Role in Chronic Pain Management

Onuţu¹,

Dîrzu²,

Petrișor³

2019

Serotonin

View full text Add to dashboard Cite

Serotonin has a particular place in the modulation of pain. Experimental studies have described 5-HT1-7 receptors and their effects on facilitation or inhibition of nociceptive input. Selective serotonin reuptake inhibitors (SSRIs) and serotoninnorepinephrine reuptake inhibitors showed efficient and safer than tricyclic antidepressants in neuropathic pain. Although there is evidence regarding the beneficial impact of SSRIs in the multimodal acute pain management, studies are still searching for the potentially favorable effect of these drugs in the prevention of chronic postoperative pain. The scope of this chapter would be to update the knowledge regarding serotonin involving in pain pathways and to highlight the importance and contribution of serotonin reuptake inhibitors in the multimodal pain management schemes.

show abstract

Citalopram for pediatric functional abdominal pain: a randomized, placebo‐controlled trial

Abstract: Overall, we found a trend toward the effectiveness of citalopram in the treatment of children with FAP. Trials with longer treatment duration in larger samples of patients are required in this regard.

Cited by 54 publications

References 25 publications

Functional abdominal pain: an integrative review study from a biopsychosocial view

Functional abdominal pain: an integrative review study from a biopsychosocial view

Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD

Serotonin Reuptake Inhibitors and Their Role in Chronic Pain Management

Contact Info

Product

Resources

About