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“…Although results of an early historically controlled study appeared promising [82], those findings were not corroborated in patients receiving cisplatin and 5-FU simultaneously [83] or in a follow-up, placebo-controlled study of patients treated with cisplatin and cyclophosphamide or cisplatin and etoposide [57]. At this stage, DDTC does not appear to be a viable option for the prevention of nephrotoxicity or neurotoxicity in either adults or children.…”
Section: Randomized ± Amifostinementioning
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“…Although results of an early historically controlled study appeared promising [82], those findings were not corroborated in patients receiving cisplatin and 5-FU simultaneously [83] or in a follow-up, placebo-controlled study of patients treated with cisplatin and cyclophosphamide or cisplatin and etoposide [57]. At this stage, DDTC does not appear to be a viable option for the prevention of nephrotoxicity or neurotoxicity in either adults or children.…”
Section: Randomized ± Amifostinementioning
“…Severe nephrotoxicity, among other toxicities, has been reported in some patients treated with cisplatin despite the use of the drug (Sastry and Kellie 2005;Katzenstein et al 2009). The side effects of amifostine might be serious and include severe hypotension, ototoxicity, nausea, dizziness, vomiting, transient decrease in serum calcium levels, infusion-related flushing, and skin reactions (Gandara et al 1990;Kemp et al 1996;Block and Gyllenhaal 2005;Hausheer et al 2011b). Subcutaneous administration seems to reduce its toxicity (Block and Gyllenhaal 2005).…”
Section: Intrinsic or Mitochondrial Apoptotic Pathwaymentioning
“…Unfortunately, CIS's therapeutic potential is limited by its ototoxicity, neurotoxicity, nephrotoxicity, and hematotoxicity (Gandara et al 1990). These toxic side effects can preclude the delivery of an adequate total dose and thereby limit CIS's therapeutic potential.…”
Section: Introductionmentioning
“…Such drugs include sodium thiosulfate (STS) (Pfeifle et al 1985), diethyldithiocarbamate (DDTC) and WR-2721 (WR) (Gandara et al 1990). The present study is focused on WR.…”
Section: Introductionmentioning