Michael ter Braak, Ralf Frederik Claas, Bianca Hegen, Sandra Labocha, Nerea Ferreirós, Josef Pfeilschifter, Andrea Huwiler, Gerhild van Echten-Deckert, Dagmar Meyer zu Heringdorf
Abbreviations: BSA, bovine serum albumin; [Ca 2+ ] i , intracellular free Ca A c c e p t e d M a n u s c r i p t 5 ABSTRACT Sphingosine-1-phosphate (S1P) acts as high affinity agonist at specific G-protein-coupled receptors, S1P  , that play important roles e.g. in the cardiovascular and immune systems. A S1P receptor modulating drug, FTY720 (fingolimod), has been effective in phase III clinical trials for multiple sclerosis. FTY720 is a sphingosine analogue and prodrug of FTY720-phosphate…
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