Cirrhosis following methotrexate administration for psoriasis

Epstein, E. H.

doi:10.1001/archderm.100.5.531

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Steatosis and Steatonecrosis1

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2003

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Cited by 16 publications

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“…Methotrexate. There are numerous reports of toxicity from this drug, used to treat leukemia and other cancers as well as patients with severe psoriasis [8,16]. The process begins with steatosis, progresses to ballooning degeneration and hepatocellular necrosis, to the development of fibrosis and ultimately to cirrhosis.…”

Section: Steatosis and Steatonecrosismentioning

confidence: 99%

Drug-Induced Chronic Liver Disease, with Emphasis on Chronic Active Hepatitis

Seeff¹

1981

Semin Liver Dis

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Section: Steatosis and Steatonecrosismentioning

confidence: 99%

Drug-Induced Chronic Liver Disease, with Emphasis on Chronic Active Hepatitis

Seeff¹

1981

Semin Liver Dis

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Methotrexate

Zachariae¹

2003

Textbook of Psoriasis

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Histopathologic findings in the liver of rheumatoid arthritis patients treated with long‐term bolus methotrexate

Aponte¹,

Petrelli²

1988

Arthritis & Rheumatism

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Twenty-three patients with severe rheumatoid arthritis were treated with oral methotrexate (MTX) for more than 10 years. MTX was given as a bolus of 5-15 mg/week; the total cumulative dose ranged from 4,690 mg to 10,230 mg. Liver biopsies were performed on 21 of the patients to assess possible fibrosis and cirrhosis. Grade I histopathologic changes were found in 13 of the 21 biopsy samples, grade I1 changes were found in 3, and grade IIIA changes (mild fibrosis) were found in 5 specimens. None of the biopsy samples showed cirrhosis. Repeat biopsies were performed on the 5 patients with grade IIIA changes while they were still taking MTX. No progression of the fibrosis was noted. Two of the 5 samples, however, were graded IIIB because of portal and perilobular inflammation. Our findings support the premise that prolonged administration of oral MTX, when given as a weekly bolus at a low dose, does not cause cirrhosis or severe fibrosis in the rheumatoid arthritis patient who does not abuse alcohol.From the

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Cirrhosis following methotrexate administration for psoriasis

Cited by 16 publications

References 0 publications

Drug-Induced Chronic Liver Disease, with Emphasis on Chronic Active Hepatitis

Drug-Induced Chronic Liver Disease, with Emphasis on Chronic Active Hepatitis

Methotrexate

Histopathologic findings in the liver of rheumatoid arthritis patients treated with long‐term bolus methotrexate

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