1969
DOI: 10.1001/archderm.100.5.523
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Cirrhosis caused by methotrexate in the treatment of psoriasis

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1970
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Cited by 16 publications
(1 citation statement)
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“…Recently, evidence of severe toxic effects on the liver have been described in several psoriatic pa¬ tients treated with methotrexate (Table 1) [4][5][6][7][8] When methotrexate is administered for malignant disease, liver abnormalities are often noted, but these are usually attrib¬ uted to frequent large doses, hepatic effects of the malignancy, other drug therapy, or combinations of these factors.9 Serum en¬ zyme levels (serum glutamic oxaloacetic transaminase [SGOT], serum glutamic pyruvic transaminase [SGPT], alkaline phosphatase) may be transiently elevated within 24 hours to three weeks after the adminis¬ tration of methotrexate and reflect acute changes of unknown etiology.10 These tests, however, are not reliable indicators of chronic changes in the liver, whereas mor¬ phologic changes, as seen in liver biopsy specimens, may better indicate chronic toxic effects.…”
mentioning
confidence: 99%
“…Recently, evidence of severe toxic effects on the liver have been described in several psoriatic pa¬ tients treated with methotrexate (Table 1) [4][5][6][7][8] When methotrexate is administered for malignant disease, liver abnormalities are often noted, but these are usually attrib¬ uted to frequent large doses, hepatic effects of the malignancy, other drug therapy, or combinations of these factors.9 Serum en¬ zyme levels (serum glutamic oxaloacetic transaminase [SGOT], serum glutamic pyruvic transaminase [SGPT], alkaline phosphatase) may be transiently elevated within 24 hours to three weeks after the adminis¬ tration of methotrexate and reflect acute changes of unknown etiology.10 These tests, however, are not reliable indicators of chronic changes in the liver, whereas mor¬ phologic changes, as seen in liver biopsy specimens, may better indicate chronic toxic effects.…”
mentioning
confidence: 99%