Circulatory Changes in Alopecia

Control of hair growth and follicle size by VEGF-mediated angiogenesis

“…These findings demonstrate that normal follicle growth and cycling in mice are dependent on VEGF-induced angiogenesis. Impaired vascularization of the hair follicle has been previously suggested to play an important role in the pathogenesis of disorders characterized by hair loss (44)(45)(46), including androgenetic alopecia (male-pattern hair loss) where baldness is associated with miniaturization of genetically predisposed follicles (3,47). Our results support this concept and suggest that some of these disorders may be potential targets for therapies aimed at increasing the vascular support of hair follicles.…”

Factors Determining Sweating Competence of Cattle Skin

“…In his study of the vasculature of the normal scalp, Cormia (1963) showed that while the large, actively growing (anagen) follicle has a rich blood supply the alkaline phosphatase activity and calibre of these vessels decreases in catagen and telogen. A similar effect is seen in cattle.…”

“…Hashimoto and Ogawa (1963) demonstrated the capillaries of rat skin with the alkaline phosphatase reaction while Johnson and Menne (1968) used it to show the capillaries of the skin in man, mouse, rat, and pig. On the other hand, Cormia and Etnyey (1961) and Cormia (1963) pointed out that not all capillaries react positively with the alkaline phosphatase technique, which therefore does not provide complete information on the vascular pattern.…”

“…The presence of alkaline phosphatase in minute blood vessels is associated with transmembranous solute transfer and may be indicative of the functional activity of the tissue (Cormia 1963). Kormano (1967) has cited a number of reports relating alkaline phosphatase activity to transport across the capillary wall.…”

Produced Alopecia Areata Based on the Focal Infection Theory and Mental Motive Theory

“…(1) Circulatory disturbances: the presence of circulatory disturbances in small vessels in the initial stage of the disease has been presented by many authors (Robinson 1888, Lévy-Franckel and Juster 1928, Wright 1929, Monacelli and Montesano 1933, Puglisi 1937, Klingmiiller 1958, Masumizu 1960, and Cormia and Ernyey 1961. Further, on the presence of arterial changes in the upper fat tissue, there have been at least two reports: Robinson (1888) has noticed fibrinous thrombi in the artery in the upper fat tissue; has reported that changes in the intima at the bifurcation of the arteries in the Lewis' cutaneous arterial plexus arc observed sometimes in the initial stage.…”