2009
DOI: 10.1007/s00262-009-0808-2
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Abstract: Cell membrane microfragments called microvesicles (MV) originating from different cells are circulating in the blood of healthy subjects and their elevated numbers are found in different diseases, including cancer. This study was designed to characterise MV present in plasma of gastric cancer patients. Since majority of MV in blood are platelets-derived (PMV), plasma samples deprived of PMV were used. In comparison to control, the number of MV in patients was significantly elevated in all stages, higher in mor… Show more

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Cited by 228 publications
(200 citation statements)
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“…Indeed, CD105 þ MVs contained proangiogenic mRNAs and miRNAs that may be involved in tumor progression and metastases. Recently, circulating MVs were described in patients with various tumors (27)(28)(29)(30)(31)(32), suggesting that they may serve as a diagnostic and prognostic tool (33)(34)(35). In the context of cancer, several studies pointed out the potential role of tumor-derived MVs in the interaction with stromal cells and in the formation of premetastatic niche (36)(37)(38)(39).…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, CD105 þ MVs contained proangiogenic mRNAs and miRNAs that may be involved in tumor progression and metastases. Recently, circulating MVs were described in patients with various tumors (27)(28)(29)(30)(31)(32), suggesting that they may serve as a diagnostic and prognostic tool (33)(34)(35). In the context of cancer, several studies pointed out the potential role of tumor-derived MVs in the interaction with stromal cells and in the formation of premetastatic niche (36)(37)(38)(39).…”
Section: Discussionmentioning
confidence: 99%
“…Proteins enriched in exosomes include proteins associated with membrane transport and fusion, including Rab GTPases and annexins, as well as proteins involved in exosome biogenesis (ESCRT complex, ALIX, TSG101). Exosomes are also enriched with heat shock proteins (HSP70, HSP90), integrins, tetraspanins (CD9, CD63, CD81, and CD82) (3,19,24), MHC class II proteins (3), epithelial cell adhesion molecules (EpCAM) (25), and members of the human epidermal receptor (HER) family (26,27). Many exosomal protein confor degradation of their contents or fuse with the plasma membrane, releasing their contents into the extracellular space in the form of exosomes (10,17).…”
Section: What Do Exosomes Contain?mentioning
confidence: 99%
“…For example, the concentration of nanovesicles was found to be increased in patients with lung cancer, 74 dermatofibroma, 87 dermatofibrosarcoma protuberans, 87 carcinoma of the oral cavity, 88 ovarian cancer, 89 and gastrointestinal cancer. 90,91 It was recently suggested that the material isolated from blood contains both nanovesicles and residual cells, and that residual cells, mostly platelets, are the origin of the nanovesicles found in isolates as an artifact of the isolation procedure. 64 However, clinical studies show differences between concentrations of nanovesicles isolated from the blood of patients with cancer and from that from healthy 54.191.190.102 on 12-May-2018 For personal use only.…”
Section: Clinical Relevance Of Cell Nanovesiclesmentioning
confidence: 99%