Circulating skin-homing T cells in atopic dermatitis. Selective up-regulation of HLA-DR, interleukin-2R, and CD30 and decrease after combined UV-A and UV-B phototherapy

Piletta, Pierre; Wirth, Susanne; Hommel, Lucette; Saurat, J.‐H.; Hauser, Conrad

doi:10.1001/archderm.132.10.1171

Cited by 32 publications

(17 citation statements)

References 26 publications

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“…In immunocompromized patients, EBV latent infection can be reactivated and induce lymphoproliferative disease, mostly B cell lymphoma [46]. Therefore, it is not known whether EBV detected in the present case may have induced lymphoproliferation or CTL response against EBV-infected cells or is a mere epiphenomenon related to atopy or molluscum contagiosum infection [47,48]. Likewise, the significance of the relative low natural killer cell count is not known.…”

Section: Discussion and Reviewmentioning

confidence: 98%

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

Abdel-Naser¹,

Tsatsou²,

Hippe³

et al. 2011

Dermatology

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Eosinophilic ulcer of the oral mucosa is a benign lesion of unclear pathogenesis mostly affecting the tongue. It has been suggested to represent a reactive pattern to several stimuli. We report on a 12-year-old boy who presented with a painless infiltrating ulcer on the gingiva of the lower jaw, which was covered by necrotic yellowish slough. There were no pathologic features of the jawbones or regional lymph nodes. Histopathological, immunohistochemical and gene rearrangement studies were in agreement with eosinophilic ulcer with predominant oligoclonal CD3+ and CD30+ T lymphocytes expressing the Epstein-Barr virus membrane protein. The ulcer resolved within 4 weeks and follow-up for 3 years revealed no evidence of recurrence. Epstein-Barr virus may have played a role in triggering this reactive lymphoproliferative disorder.

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Section: Discussion and Reviewmentioning

confidence: 98%

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

Abdel-Naser¹,

Tsatsou²,

Hippe³

et al. 2011

Dermatology

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“…196 UVA/B combination therapy has been shown to decrease the number of HLA-DR + T cells in AD patients. 197 …”

Section: Systemic Antipruritic Agentsmentioning

confidence: 99%

Management of Itch in Atopic Dermatitis

Hong¹,

Buddenkotte²,

Berger³

et al. 2011

Seminars in Cutaneous Medicine and Surgery

129

105

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Atopic dermatitis is a common, pruritic, inflammatory skin disorder. Chronic, localized, or even generalized pruritus is the diagnostic hallmark of atopic dermatitis, and its management remains a challenge for physicians. The threshold for itch and alloknesis is markedly reduced in these patients, and infections can promote exacerbation and thereby increase the itch. Modern management consists of anti-inflammatory, occasionally antiseptic, as well as antipruritic therapies to address the epidermal barrier as well as immunomodulation or infection. Mild forms of atopic dermatitis may be controlled with topical therapies, but moderate-to-severe forms often require a combination of systemic treatments consisting of antipruritic and immunosuppressive drugs, phototherapy, and topical compounds. In addition, patient education and a therapeutic regimen to help the patient cope with the itch and eczema are important adjuvant strategies for optimized long-term management. This review highlights various topical, systemic, and complementary and alternative therapies, as well as provide a therapeutic ladder for optimized long-term control of itch in atopic dermatitis.

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“…Main factors that are suggested to influence asthma in high-altitude climate therapy are allergen avoidance, increased cortisol and catecholamine level, the dry air and high UV light exposure [15][16][17][18]. However, only little is known about the underlying immunological mechanisms [19,20].…”

Section: Introductionmentioning

confidence: 99%

High‐Altitude Climate Therapy Reduces Local Airway Inflammation and Modulates Lymphocyte Activation

Karagiannidis¹,

Hense

Rueckert³

et al. 2006

Scand J Immunol

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High-altitude climate therapy is a well-established therapeutic option, which improves clinical symptoms in asthma. However, little is known about the underlying immunological mechanisms. The study investigates the influence of high-altitude climate therapy on airway inflammation and cellular components of specific and unspecific immune response. Exhaled NO significantly decreased within 3 weeks of therapy in patients with allergic and intrinsic, moderate and severe asthma. Interleukin-10 (IL-10)-secreting peripheral blood mononuclear cells (PBMC) increased within 3 weeks of therapy in six of 11 patients, whereas transforming growth factor-b 1 -secreting PBMC remained stable. Furthermore, monocyte activation, assessed by CD80 expression significantly decreased during therapy. The frequency of CRTH2-expressing T cells decreased, while regulatory T cells (T reg ) remained stable. FOXP3 and GATA-3 mRNA expression in CD4 þ T cells did not change, while interferon-g and IL-13 mRNA expression decreased in eight of 10 patients. The current data demonstrate that high-altitude climate therapy reduces local airway inflammation. Furthermore, monocytes switch towards a tolerogenic phenotype under high-altitude climate therapy. The T reg /Th2 ratio increases; however, because of the absence of antigens/allergens, no de novo differentiation of Th2 nor T reg cells is observed. The high-altitude climate therapy therefore may form the immunological basis for the endogenous control of allergen-driven diseases.

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Circulating skin-homing T cells in atopic dermatitis. Selective up-regulation of HLA-DR, interleukin-2R, and CD30 and decrease after combined UV-A and UV-B phototherapy

Cited by 32 publications

References 26 publications

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

Management of Itch in Atopic Dermatitis

High‐Altitude Climate Therapy Reduces Local Airway Inflammation and Modulates Lymphocyte Activation

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