2020
DOI: 10.3390/cells9040827
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability. Although recent pharmaceutical advances have improved the treatment of RA, patients often inquire about dietary interventions to improve RA symptoms, as they perceive pain and/or swelling after the consumption or avoidance of certain foods. There is evidence that some foods have pro- or anti-inflammatory effects mediated by diet-related m… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
38
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 58 publications
(39 citation statements)
references
References 212 publications
(213 reference statements)
1
38
0
Order By: Relevance
“…An apparent difference of metabolomic profiles was observed in these studies. Serum metabolomic analyses were also conducted in RA (5), and obviously, different metabolomic profiles were reported. Profiles of some metabolites were significantly different between ILD(+)RA and CLD(-)RA, but the number of the metabolites with significant differences between ILD(+)RA and CLD(-)RA seemed to be smaller than the difference between idiopathic pulmonary fibrosis patients and healthy controls or RA and healthy controls.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…An apparent difference of metabolomic profiles was observed in these studies. Serum metabolomic analyses were also conducted in RA (5), and obviously, different metabolomic profiles were reported. Profiles of some metabolites were significantly different between ILD(+)RA and CLD(-)RA, but the number of the metabolites with significant differences between ILD(+)RA and CLD(-)RA seemed to be smaller than the difference between idiopathic pulmonary fibrosis patients and healthy controls or RA and healthy controls.…”
Section: Discussionmentioning
confidence: 99%
“…Systematic investigations of metabolic pathways and low molecular weight compounds have mostly been conducted to clarify the pathogenesis of cancer and to generate cancer biomarkers (4). Some metabolomic analyses were also conducted separately in RA (5) or idiopathic pulmonary fibrosis (6)(7)(8) but rarely for RA-ILD. Here, we analyzed serum metabolomic profiles of ILD in RA to generate novel biomarkers for RA-ILD.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, our sample size was limited; thus, validation using other methods is warranted. Finally, correlations between top findings and BMI were low (Pearson’s r < 0.3), and due to the low number of patients per group, we did not take into consideration other factors such as comorbidity, food intake and lifestyle factors, such as smoking, which may have influenced metabolic profiles [ 55 ].…”
Section: Discussionmentioning
confidence: 99%
“…Choline and related metabolites, including TMAO, mainly deriving from diet, have been associated with cardiovascular inflammation. These metabolites have been identified in blood samples, synovial fluid and tissue of mice models of arthritis as well as in human studies on CV risk, but their role in RA has not been fully investigated [45].…”
Section: Dietary Habits and The Risk Of Ra Developmentmentioning
confidence: 99%