Circulating pentraxin 3 is positively associated with chronic hyperglycemia but negatively associated with plasma aldosterone concentration

Abstract

Pentraxin 3 (PTX3) is reported to be a vascular inflammation marker providing prognostic information of vasculopathy. Until today, however, the effect of aldosterone or oxidative stress on the regulation of PTX3 is unknown. In present study, we investigated to find regulative factors, especially aldosterone and oxidative stress, on PTX3. Serum PTX3 levels were measured in 75 patients (45 male and 30 women, aged 55.1±13.4 year-old (mean±SD)) with various endocrine disorders including 47 with diabetes, 24 with primary aldosteronism (PA). All participants were free from cardio vascular diseases and diabetic retinopathy. Serum PTX3 level was significantly lower in patients with PA than without PA and was significantly higher in patients with diabetes than without diabetes. PTX3 was significantly correlated with glycated hemoglobin (HbA1c), urinary albumin excretion (UAE) and plasma aldosterone concentration (PAC) (r = 0.431, P<0.001; r = 0.313, P = 0.009; r = -0.375, P = 0.004). A stepwise multiple regression analysis chose HbA1c and UAE as independent determinants of PTX3 (β = 0.282, P<0.001; β = 0.783, P<0.001). On the other hand, PTX3 was not significantly correlated with HbA1c and UAE but significantly negatively correlated with PAC in patients with diabetes. Therefore, it might be suggested that PTX3 is positively regulated by chronic hyperglycemia but negatively regulated by aldosterone, and is associated with urinary albumin excretion as a micro vasculopathy.

Study of serum pentraxin 3 level in patients with diabetic nephropathy

“…This study also revealed that there was a highly significant correlation between glycemic control (HbA 1 c) and development of DN as HbA 1 c was elevated in the DN groups more than in the control and diabetic without DN groups. These results are in accordance with Takashi et al [8]. In agreement with Wang et al [12] and Uzun et al [9], this study showed that there is a highly significant correlation between FBG and 2hBBPG, and the development of DN.…”

“…This is in accordance with Wang et al [12] and Rutledge et al [19] who stated that there is a significant association between serum TGs and DN. In contrast to this study, Takashi et al [8] mentioned that there is no association between serum TGs and DN. However, this study revealed that there was no significant association between the development of DN with serum total cholesterol, HDL, and LDL.…”

“…However, this study revealed that there was no significant association between the development of DN with serum total cholesterol, HDL, and LDL. Wang et al [12] and Takashi et al [8] mentioned that DN is significantly associated with serum HDL and not significantly associated with total cholesterol and LDL. Uzun et al's [9] study mentioned that dyslipidemia has no role on the development of DN as there was no significant association between DN and total cholesterol, TG, HDL, and LDL.…”

“…But levels of these markers may be correlated with many factors other than inflammation. So, there is a need for more specific markers related to DN [8].…”

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

“…64 In a sample of patients with endocrine disorders, serum pentraxin-3 levels were negatively correlated with plasma aldosterone concentrations, suggesting that aldosterone may be a negative regulator of pentraxin-3. 65 However, there is conflicting evidence regarding the influence of pentraxin-3 on CVD due to pentraxin-3 having both beneficial and detrimental cardiovascular effects that are context dependent. 66…”