Circulating Oxidized Low Density Lipoprotein Levels

Toshima, Shunichi; Hasegawa, Akira; Kurabayashi, Masahiko; Itabe, Hiroyuki; Takano, Tatsuya; Sugano, Jinpei; Shimamura, Kazutoshi; Kimura, Junji; Michishita, Ichiro; Suzuki, Toru; Nagai, Ryozo

doi:10.1161/01.atv.20.10.2243

Cited by 365 publications

(142 citation statements)

References 35 publications

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“…8 In another study, plasma levels of oxidized LDL were significantly higher in patients with CHD than in controls, and were not correlated with other major risk factors. 9 Natural antioxidants (ie, ␤-carotene, vitamin C, and vitamin E) have been used as a potential strategy to reduce damage caused by oxidized LDL in patients with or at high risk for CHD, but the majority of clinical trials have not shown reductions in CHD events with this approach. 10 More clinically reliable markers of oxidative stress or the development of more effective antioxidant therapies might make this strategy more useful.…”

Section: Inflammatory Mechanismsmentioning

confidence: 99%

Inflammation in Atherosclerosis and Implications for Therapy

2004

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Abstract-Atherosclerosis is now understood to be a disease characterized by inflammation that results in a host of complications, including ischemia, acute coronary syndromes (unstable angina pectoris and myocardial infarction), and stroke. Inflammation may be caused by a response to oxidized low-density lipoproteins, chronic infection, or other factors; and markers of this process, such as C-reactive protein, may be useful to predict an increased risk of coronary heart disease. Thus, we believe that inflammatory processes may be potential targets of therapy in preventing or treating atherosclerosis and its complications.

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Section: Inflammatory Mechanismsmentioning

confidence: 99%

Inflammation in Atherosclerosis and Implications for Therapy

2004

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“…Given the clinical atherogenic role of oxidized-low density lipoprotein (ox-LDL) numerous efforts have been made to detect its level in circulation. Hasegawa and workers (4), Toshima et al (5) have developed immunological technique like sandwich-ELISA. Though the major obstacle of these techniques is the difficulty in detecting the minute amount of ox-LDL, and lack of specificity of the antibody, due to the large size of apoprotein B.…”

Section: Introductionmentioning

confidence: 99%

Oxidised LDL, HDL cholesterol, LDL cholesterol levels in patients of coronary artery disease

Ghosh

Mishra

Rao

et al. 2006

Indian J Clin Biochem

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Coronary artery disease is a major cause of morbidity and has various risk factors. Lipid profile i.e. low HDL-cholesterol, high LDL cholesterol, high total cholesterol, high triglycerides playing important role in its causation. Recently interest has been shown in the oxidized fraction of LDL as one of the risk factors. In the present study 60 age and sex matched normal healthy individuals were taken as controls and 60 patients of CAD were taken. Cholesterol was measured by enzymatic method, HDL cholesterol by phosphotungstate precipitation method. Serum levels of LDL fraction of cholesterol was measured by a new and simpler method of precipitation. Result was expressed as mol/L of diene conjugates. It was observed that LDL cholesterol, VLDL cholesterol, total cholesterol, total cholesterol:HDL cholesterol, LDL cholesterol:HDL cholesterol were significantly raised and HDL cholesterol was significantly low in patients. (p< 0.001). Though HDL cholesterol was significantly raised in females as compared to males in both the groups (p<0.001). Serum level of total cholesterol, oxidized LDL:HDL cholesterol were also raised significantly (p<0.05). The level of oxidized LDL showed an increasing trend in patients.

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“…It has been reported that LOX-1 binds to oxidized LDL [31], and increases in oxidized LDL levels of expression are indicative of cardiovascular dysfunction [18]. We therefore analyzed LOX-1 mRNA expressions in the hearts of the transgenic mice, but no difference in their levels of expression was observed (data not shown).…”

Section: Discussionmentioning

confidence: 93%

Analysis of Gender Difference of Cardiac Risk Biomarkers Using hGH-Transgenic Mice

Naraoka

Ito²,

Suzuki³

et al. 2006

Exp. Anim.

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We investigated gender difference in the effects of chronic exposure to human growth hormone (hGH) on cardiac risk biomarkers using transgenic mice with non-pulsatile circulating hGH. Blood plasma was obtained from transgenic and control mice at 8, 12, and 16 weeks of age, and was used for the measurement of hGH and the following cardiac risk biomarkers: total cholesterol (CHO), triglyceride (TG), HDL cholesterol (HDL), LDL cholesterol (LDL), non esterified free fatty acids (NEFA), and lipid peroxides (LPO

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Circulating Oxidized Low Density Lipoprotein Levels

Cited by 365 publications

References 35 publications

Inflammation in Atherosclerosis and Implications for Therapy

Inflammation in Atherosclerosis and Implications for Therapy

Oxidised LDL, HDL cholesterol, LDL cholesterol levels in patients of coronary artery disease

Analysis of Gender Difference of Cardiac Risk Biomarkers Using hGH-Transgenic Mice

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