Circulating miR-30a-5p as a prognostic biomarker of left ventricular dysfunction after acute myocardial infarction

Abstract

Left ventricular (LV) dysfunction after acute myocardial infarction (AMI) is associated with an increased risk of heart failure (HF) development. Diverse microRNAs (miRNAs) have been shown to appear in the bloodstream following various cardiovascular events. The aim of this study was to identify prognostic miRNAs associated with LV dysfunction following AMI. Patients were divided into subgroups comprising patients who developed or not LV dysfunction within six months of the infarction. miRNA profiles were determined in plasma and serum samples of the patients on the first day of AMI. Levels of 14 plasma miRNAs and 16 serum miRNAs were significantly different in samples from AMI patients who later developed LV dysfunction compared to those who did not. Two miRNAs were up-regulated in both types of material. Validation in an independent group of patients, using droplet digital PCR (ddPCR) confirmed that miR-30a-5p was significantly elevated on admission in those patients who developed LV dysfunction and HF symptoms six months after AMI. A bioinformatics analysis indicated that miR-30a-5p may regulate genes involved in cardiovascular pathogenesis. This study demonstrates, for the first time, a prognostic value of circulating miR-30a-5p and its association with LV dysfunction and symptoms of HF after AMI.

Circulating miR-320a as a Predictive Biomarker for Left Ventricular Remodelling in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention

“…Recent reports have described the expression patterns of circulating miRNAs in patients with myocardial infarction [23][24][25]. However, there are only a few studies describing miRNAs in STEMI patients after PPCI and their possible role as prognostic markers for the development of LVAR [26][27][28]. In this study, we examined the time course of the expression of miRNAs in STEMI patients after PPCI, and assessed the specific role of miR-320a as a prognostic biomarker of LVAR.…”

Serum microRNA in patients undergoing atrial fibrillation ablation

“…Accordingly, miRNAs are viewed as regulators of the expression of genes directly or indirectly involved in important physiological and pathophysiological processes. One advantage of miRNAs is that they can be detected in the circulation, making them attractive as potential biomarkers for the diagnosis and prognosis of diverse diseases 5 .…”

Significant changes in synovial fluid microRNAs after high tibial osteotomy in medial compartmental knee osteoarthritis: Identification of potential prognostic biomarkers

“…miR-30a-5p has been previously implicated in the progression of lung [21], colorectal [22], and other types of cancers. Previously, the miR-30a-5p family has been found to be involved in the cardiovascular pathophysiology that leads to myocardial infarction [23,24]. miR-30a-5p is also associated with rheumatoid arthritis and inflammation in septic conditions [25,26].…”