Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction

Ai, Jing; Zhang, Rong; Li, Yue; Pu, Jielin; Lu, Yanjie; Jiao, Jundong; Li, Kang; Yu, Bo; Li, Zhu-qin; Wang, Rongrong; Wang, Lihong; Li, Qiang; Wang, Ning; Shan, Hongli; Li, Zhongyu; Yang, Baofeng

doi:10.1016/j.bbrc.2009.11.005

Cited by 482 publications

(361 citation statements)

References 24 publications

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“…Taken together, it appears that irradiation-induced suppression of miR-1 might be beneficial for the heart. Noteworthy, miR-1 is released to blood circulation thus it has a potential to be a novel biomarker of cardiac injury (Ai et al 2010) and possibly proarrhythmogenic state.…”

Section: Discussionmentioning

confidence: 99%

Myocardial connexin-43 and PKC signalling are involved in adaptation of the heart to irradiation-induced injury: Implication of miR-1 and miR-21

Viczenczová¹,

Bacova²,

T³

et al. 2016

gpb

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Abstract. Intercellular connexin-43 (Cx43) channels are essential for electrical coupling and direct cardiac cell to cell communication to ensure heart function. Expression of Cx43 is altered due to stressful conditions and also affected by the alterations in extracellular matrix. We aimed to explore the effect of chest irradiation on myocardial expression of Cx43 and miR-1 which regulates GJA1 gene transcription for Cx43. Implication of miR-21 that regulates expression of extracellular matrix proteins and PKC signalling that may affect Cx43-mediated coupling was examined as well. Western blot and real-time PCR analyses revealed that six weeks after the exposure of healthy Wistar rats chest to single irradiation of 25 Gy significant myocardial alterations were observed: 1) increase of total Cx43 protein expression and its functional phosphorylated forms; 2) suppressed levels of miR-1; 3) enhanced expression of PKCε which phosphorylates Cx43; 4) increase of miR-21 levels; 5) increase of PKCδ expression. These results suggest that irradiation causes post-transcriptional regulation of myocardial Cx43 expression by miR-1 possibly through miR-21 and PKC signalling. We conclude that single dose of irradiation has the potential to enhance myocardial intercellular communication that might be beneficial for the heart that needs to be investigated in details in further studies.

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Section: Discussionmentioning

confidence: 99%

Myocardial connexin-43 and PKC signalling are involved in adaptation of the heart to irradiation-induced injury: Implication of miR-1 and miR-21

Viczenczová¹,

Bacova²,

T³

et al. 2016

gpb

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“…Increasing lines of evidence have been rapidly evolving for the crucial roles of miRNAs in regulating diverse aspects of cardiac function and progression of HF 4, 5. And notably microRNA‐1 (miR‐1), a cardiac‐enriched miRNA, is in most close relation to heart conditions, and the changes in its expression have been discovered in a variety of heart diseases 6, 7, 8, 9, 10. Our previous report revealed that outcomes of miR‐1 overexpression induced adverse structural remodelling, which impaired cardiac contractile and diastolic function and even caused HF 11.…”

Section: Introductionmentioning

confidence: 99%

Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

Zhang

Niu

et al. 2018

J Cellular Molecular Medi

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MicroRNA‐1 (miR‐1) stands out as the most prominent microRNA (miRNA) in regulating cardiac function and has been perceived as a new potential therapeutic target. Lycium barbarum polysaccharides (LBPs) are major active constituents of the traditional Chinese medicine based on L. barbarum. The purpose of this study was to exploit the cardioprotective effect and molecular mechanism of LBPs underlying heart failure. We found that LBPs significantly reduced the expression of myocardial miR‐1. LBPs improved the abnormal ECG and indexes of cardiac functions in P‐V loop detection in transgenic (Tg) mice with miR‐1 overexpression. LBPs recovered morphological changes in sarcomeric assembly, intercalated disc and gap junction. LBPs reversed the reductions of CaM and cMLCK, the proteins targeted by miR‐1. Similar trends were also obtained in their downstream effectors including the phosphorylation of MLC2v and both total level and phosphorylation of CaMKII and cMyBP‐C. Collectively, LBPs restored adverse structural remodelling and improved cardiac contractile dysfunction induced by overexpression of miR‐1. One of the plausible mechanisms was that LBPs down‐regulated miR‐1 expression and consequently reversed miR‐1‐induced repression of target proteins relevant to myocardial contractibility. LBPs could serve as a new, at least a very useful adjunctive, candidate for prevention and therapy of heart failure.

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“…Four cardiac miRNAs (miR-208a, miR-499, miR-1, and miR-133) are found to be consistently elevated in plasma of AMI patients within hours after the onset of infarction. (130)(131)(132)(133)(134)(135)(136)(137)(138) Of these 4 miRNAs, miR-208a, which is encoded by an intron of the aMHC gene, is to the best of our knowledge the only heart-specific miRNA. (139) The other 3 miRNAs (miR-499, miR-1, and miR-133), besides being highly expressed in the heart, are also expressed in skeletal muscle.…”

Section: Mirnas In Glucose Homeostasismentioning

confidence: 99%

MicroRNAs in Cardiometabolic Diseases

Meiliana

Wijaya

2013

Indones Biomed J

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BACKGROUND: MicroRNAs (miRNAs) are ~22-nucleotide noncoding RNAs with critical functions in multiple physiological and pathological processes. An explosion of reports on the discovery and characterization of different miRNA species and their involvement in almost every aspect of cardiac biology and diseases has established an exciting new dimension in gene regulation networks for cardiac development and pathogenesis.CONTENT: Alterations in the metabolic control of lipid and glucose homeostasis predispose an individual to develop cardiometabolic diseases, such as type 2 diabetes mellitus and atherosclerosis. Work over the last years has suggested that miRNAs play an important role in regulating these physiological processes. Besides a cell-specific transcription factor profile, cell-specific miRNA-regulated gene expression is integral to cell fate and activation decisions. Thus, the cell types involved in atherosclerosis, vascular disease, and its myocardial sequelae may be differentially regulated by distinct miRNAs, thereby controlling highly complex processes, for example, smooth muscle cell phenotype and inflammatory responses of endothelial cells or macrophages. The recent advancements in using miRNAs as circulating biomarkers or therapeutic modalities, will hopefully be able to provide a strong basis for future research to further expand our insights into miRNA function in cardiovascular biology. ISI:Perubahan kendali metabolisme lemak dan homeostasis glukosa pada individu dapat memicu berkembangnya penyakit kardiometabolik seperti diabetes melitus tipe 2 dan aterosklerosis. Penelitian yang dilakukan pada dasawarsa terakhir telah menunjukkan bahwa miRNA memiliki peran penting dalam pengaturan proses fisiologi ini. Selain profil faktor transkripsi spesifik sel, ekspresi gen yang diregulasi oleh miRNA mempengaruhi tujuan akhir perkembangan dan keputusan aktivasi sel. Jadi, tipe sel yang terlibat dalam aterosklerosis, penyakit vaskular, dan kerusakan miokardial mungkin diregulasi secara berbeda oleh miRNA yang berlainan, melalui proses pengaturan yang sangat rumit, misalnya fenotipe sel otot polos dan respon inflamasi sel endotel atau makrofag. Perkembangan terakhir dalam hal penggunaan miRNA sebagai biomarker atau modalitas terapi diharapkan dapat menjadi dasar yang kuat untuk penelitian lebih lanjut, sehingga dapat memperkaya pemahaman kita mengenai fungsi miRNA pada biologi kardiovaskular. RINGKASAN:MiRNA adalah noncoding RNA yang kecil, berfungsi sebagai pengatur post-transkripsi pada ekspresi gen. MiRNA merupakan modulator potensial pada berbagai proses dan patologi biologi. Penemuan yang ada menunjukkan pentingnya peran miRNA pada vaskulatur, alur metabolisme lemak, dan homeostasis glukosa. Abstract Abstrak R E V I E W A R T I C L E

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Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction

Cited by 482 publications

References 24 publications

Myocardial connexin-43 and PKC signalling are involved in adaptation of the heart to irradiation-induced injury: Implication of miR-1 and miR-21

Myocardial connexin-43 and PKC signalling are involved in adaptation of the heart to irradiation-induced injury: Implication of miR-1 and miR-21

Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

MicroRNAs in Cardiometabolic Diseases

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