Circulating metabolites of strawberry mediate reductions in vascular inflammation and endothelial dysfunction in db/db mice

Petersen, Chrissa; Bharat, Divya; Cutler, Brett; Gholami, Samira; Denetso, Christopher; Mueller, Jaime A.; Cho, Jae Min; Kim, Ji Seok; Symons, J. David; Babu, Pon Velayutham Anandh

doi:10.1016/j.ijcard.2018.04.040

Cited by 29 publications

(69 citation statements)

References 45 publications

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“…Blueberries are high in anthocyanins, in addition to other polyphenolic compounds [ 3 ], and have anti-oxidant and anti-inflammatory properties [ 49 , 50 , 51 , 52 ] which contribute to improved vascular function and increased insulin sensitivity [ 53 , 54 ]. Anthocyanins are not digested or metabolized in the stomach or upper intestine and remain intact until reaching the large intestine, where they are converted to phenolic acids by commensal bacteria [ 12 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice

et al. 2019

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The antioxidant and anti-inflammatory properties of blueberries improve vascular function and insulin sensitivity. However, the bioavailability of the active compounds in blueberries is largely dependent on the gut microbiota, which may themselves be altered by blueberry components. The objective of the current study was to explore a possible sex-dependent modulation of the gut microbiota following supplementation with blueberries in adult mice. Eight-week-old C57BL/6J mice (n = 7–10/group) were provided with control or blueberry-containing diets (5% freeze-dried powder) for 4 weeks. Body weight, composition, and food intake were measured weekly. Genomic DNA was isolated from the cecal contents for 16S rRNA sequencing. Blueberry feeding decreased a-diversity (operational taxonomical unit abundance) and altered b-diversity (p < 0.05). At the phylum level, the Firmicutes to Bacteroidetes ratio was significantly lower in the blueberry-fed groups (p < 0.001), along with increased Tenericutes and decreased Deferribacteres. At the genus level, blueberry feeding led to sexually-dimorphic differences, which were associated with predicted metabolic pathways. Pathways such as fatty acid and lipid metabolism were significantly different and demonstrated a stronger association with microbes in the male. To summarize, blueberry supplementation led to sexually-dimorphic global changes in the gut microbiome, which could possibly contribute to physiological changes in mice.

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Section: Discussionmentioning

confidence: 99%

Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice

et al. 2019

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“…CCL2, a chemokine that recruits monocytes and macrophages, is highly expressed in epididymal adipose tissue of db/db mice [ 186 ], whereas the expression of nucleotide-binding-oligomerization domain type-1 (NOD1) is suppressed [ 186 ]. Inflammation also affects the vasculature and inflammatory markers such as monocyte chemotactic protein-1 (MCP-1), vascular cell adhesion molecule-1, (VCAM1), intercellular adhesion molecule-1 (ICAM1) or E-selectin are increased in aortic and carotid vessels from db/db mice [ 190 ]. Likewise, oxidative stress markers, as like 3NT-positive protein, are increased in serum [ 191 ].…”

Section: Diet Inflammation and Gut Microbiota In T2dm Modelsmentioning

confidence: 99%

Alzheimer’s Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models

et al. 2021

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Alzheimer’s disease (AD) is the most common cause of dementia. Epidemiological studies show the association between AD and type 2 diabetes (T2DM), although the mechanisms are not fully understood. Dietary habits and lifestyle, that are risk factors in both diseases, strongly modulate gut microbiota composition. Also, the brain-gut axis plays a relevant role in AD, diabetes and inflammation, through products of bacterial metabolism, like short-chain fatty acids. We provide a comprehensive review of current literature on the relation between dysbiosis, altered inflammatory cytokines profile and microglia in preclinical models of AD, T2DM and models that reproduce both diseases as commonly observed in the clinic. Increased proinflammatory cytokines, such as IL-1β and TNF-α, are widely detected. Microbiome analysis shows alterations in Actinobacteria, Bacteroidetes or Firmicutes phyla, among others. Altered α- and β-diversity is observed in mice depending on genotype, gender and age; therefore, alterations in bacteria taxa highly depend on the models and approaches. We also review the use of pre- and probiotic supplements, that by favoring a healthy microbiome ameliorate AD and T2DM pathologies. Whereas extensive studies have been carried out, further research would be necessary to fully understand the relation between diet, microbiome and inflammation in AD and T2DM.

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“…Similar to blueberries, strawberries have been implicated in reducing inflammation in vascular endothelial cells. db / db mice, a mouse model of genetic obesity and type 2 diabetes, were used to assess the impact of strawberry consumption on endothelial cell inflammation [ 93 ]. Addition of freeze-dried strawberry powder (2.35% of the diet by weight) reduced monocyte binding and inflammation in aortic vessels in db / db mice.…”

Section: Anti-inflammatory Effects Of Strawberriesmentioning

confidence: 99%

Berries as a Treatment for Obesity-Induced Inflammation: Evidence from Preclinical Models

et al. 2021

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Inflammation that accompanies obesity is associated with the infiltration of metabolically active tissues by inflammatory immune cells. This propagates a chronic low-grade inflammation associated with increased signaling of common inflammatory pathways such as NF-κB and Toll-like receptor 4 (TLR4). Obesity-associated inflammation is linked to an increased risk of chronic diseases, including type 2 diabetes, cardiovascular disease, and cancer. Preclinical rodent and cell culture studies provide robust evidence that berries and their bioactive components have beneficial effects not only on inflammation, but also on biomarkers of many of these chronic diseases. Berries contain an abundance of bioactive compounds that have been shown to inhibit inflammation and to reduce reactive oxygen species. Therefore, berries represent an intriguing possibility for the treatment of obesity-induced inflammation and associated comorbidities. This review summarizes the anti-inflammatory properties of blackberries, blueberries, strawberries, and raspberries. This review highlights the anti-inflammatory mechanisms of berries and their bioactive components that have been elucidated through the use of preclinical models. The primary mechanisms mediating the anti-inflammatory effects of berries include a reduction in NF-κB signaling that may be secondary to reduced oxidative stress, a down-regulation of TLR4 signaling, and an increase in Nrf2.

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Circulating metabolites of strawberry mediate reductions in vascular inflammation and endothelial dysfunction in db/db mice

Cited by 29 publications

References 45 publications

Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice

Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice

Alzheimer’s Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models

Berries as a Treatment for Obesity-Induced Inflammation: Evidence from Preclinical Models

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