Circulating Immunoreactive Interleukin-6 in Cystic Fibrosis

Nixon, Lisette Sheena; Yung, Bernard; Bell, S. C.; Elborn, J. Stuart; Shale, Dennis J.

doi:10.1164/ajrccm.157.6.9704086

Cited by 118 publications

(97 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in that group, no significant correlations were found between cytokine levels and bone density. Our present findings differ from those reported previously showing elevated cytokines in patients with CF [29][30][31][32][33][34]. One explanation is the use of inhaled glucocorticoids by all study participants in the current sample.…”

Section: Discussioncontrasting

confidence: 99%

“…The proresorptive cytokines, tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and interleukin 6 (IL-6) [28], stimulate bone resorption and/or osteoclast formation. Two reports have shown that TNF-α production by lung macrophages was elevated in patients with CF [29,30], and other studies have shown elevations of serum TNF-α [31], IL-1β [30], and IL-6 [30,32,33] concentrations in these patients. Haworth et al [34] found an inverse correlation between skeletal losses and serum IL-6 concentrations over a 1-year period in a study of young adults with CF.…”

Section: Introductionmentioning

confidence: 86%

See 1 more Smart Citation

Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosis

et al. 2006

View full text Add to dashboard Cite

Introduction-Patients with cystic fibrosis (CF) are known to be at risk for early osteoporosis, and the mechanisms that mediate bone loss are still being delineated. The aim of the present investigation was to investigate if a correlation exists in these patients between skeletal measurements by dual-energy x-ray absorptiometry (DXA) and two anabolic factors, dehydroepiandrosterone (DHEA) and insulin-like growth factor I (IGF-I), and proresorptive factors such as the cytokines interleukin-1β, tumor necrosis factor α, and interleukin-6.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 86%

Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosis

et al. 2006

View full text Add to dashboard Cite

show abstract

“…An association between serum IL-8 levels and bacterial numbers or inflammation was not observed. While studies in older CF patients with chronic lung disease report modest elevations of circulating inflammatory mediators [26,27], these may only represent increased local production of cytokines and may not be of any pathophysiological significance.…”

Section: Discussionmentioning

confidence: 98%

Interlobar differences in bronchoalveolar lavage fluid from children with cystic fibrosis

Grimwood²,

et al. 2001

View full text Add to dashboard Cite

Bronchoalveolar lavage (BAL) performed in specialist centres has improved the understanding of infant cystic fibrosis (CF) lung disease. As most researchers sample from a single lobe, it was determined whether BAL results could be generalized to other lung segments.Thirty-three CF children, aged 1.5–57 months, underwent in random order sequential BAL of their right middle and lingula lobes. Specimens from each lobe had separate quantitative bacteriology, cytology and cytokine analysis.Bacterial counts ≥1×105colony forming units (cfu)·mL−1were observed in nine (27%) subjects, including six involving only the right middle lobe. These six children had similar inflammatory indices in their right middle and lingula lobes, and interleukin (IL)-8 concentrations in the latter were significantly higher than that observed within the lingula lobes of the 24 CF children with bacterial counts <1×105 cfu·mL−1. Lingula neutrophil and IL-8 levels correlated best with right middle lobe bacteria numbers.This observational study in cystic fibrosis children suggests that while inflammation is detected in both lungs, bacterial distribution may be more inhomogeneous. Bronchoalveolar lavage microbiological findings from a single lobe may therefore, not be generalized to other lung segments. When performing bronchoalveolar lavage in cystic fibrosis children, it is important to sample from multiple sites.

show abstract

“…We did not assess airway inflammation and cannot determine whether changes in systemic measures of inflammation reflect inflammatory changes in the lungs. Three studies have reported modest correlations between blood-based biomarker levels and select markers of airway inflammation (IL-8, TNF-a, TGF-b 1 ) during CF pulmonary exacerbations (31)(32)(33). This suggests that assay of systemic inflammatory markers may, to some extent, reflect inflammatory burden in the lungs.…”

Section: O2 Saturationmentioning

confidence: 99%

Effect of Treatment of Cystic Fibrosis Pulmonary Exacerbations on Systemic Inflammation

et al. 2015

View full text Add to dashboard Cite

Rationale: In cystic fibrosis (CF), pulmonary exacerbations present an opportunity to define the effect of antibiotic therapy on systemic measures of inflammation.Objectives: Investigate whether plasma inflammatory proteins demonstrate and predict a clinical response to antibiotic therapy and determine which proteins are associated with measures of clinical improvement.Methods: In this multicenter study, a panel of 15 plasma proteins was measured at the onset and end of treatment for pulmonary exacerbation and at a clinically stable visit in patients with CF who were 10 years of age or older.Measurements and Main Results: Significant reductions in 10 plasma proteins were observed in 103 patients who had paired blood collections during antibiotic treatment for pulmonary exacerbations. Plasma C-reactive protein, serum amyloid A, calprotectin, and neutrophil elastase antiprotease complexes correlated most strongly with clinical measures at exacerbation onset. Reductions in C-reactive protein, serum amyloid A, IL-1ra, and haptoglobin were most associated with improvements in lung function with antibiotic therapy. Having higher IL-6, IL-8, and a 1 -antitrypsin (a1AT) levels at exacerbation onset were associated with an increased risk of being a nonresponder (i.e., failing to recover to baseline FEV 1 ). Baseline IL-8, neutrophil elastase antiprotease complexes, and a1AT along with changes in several plasma proteins with antibiotic treatment, in combination with FEV 1 at exacerbation onset, were predictive of being a treatment responder. Conclusions:Circulating inflammatory proteins demonstrate and predict a response to treatment of CF pulmonary exacerbations. A systemic biomarker panel could speed up drug discovery, leading to a quicker, more efficient drug development process for the CF community.

show abstract

Circulating Immunoreactive Interleukin-6 in Cystic Fibrosis

Cited by 118 publications

References 29 publications

Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosis

Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosis

Interlobar differences in bronchoalveolar lavage fluid from children with cystic fibrosis

Effect of Treatment of Cystic Fibrosis Pulmonary Exacerbations on Systemic Inflammation

Contact Info

Product

Resources

About