Circulating hyaluronate in psoriasis

Abstract

A radioassay method allowing measurements of low concentrations of circulating hyaluronate was used in a study of serum hyaluronate concentrations in 44 patients with psoriasis. Twenty-three of them had only skin lesions and 21 had both skin lesions and arthropathy. In both of these groups significantly elevated serum levels of hyaluronate were found. The highest values were observed in those with widespread and active skin disease and/or active arthritis. Serum hyaluronate positively correlated with the plasma concentrations of alpha 1-antitrypsin and haptoglobin and also with ESR, which may indicate a relationship between acute inflammation and increased production of hyaluronate. Seven patients with widespread atopic dermatitis included for comparison had normal hyaluronate values. In blister fluid from lesional skin in two patients with acute psoriasis, very high concentrations of hyaluronate were found, in comparison with the concentrations in blister fluid from non-involved skin. The increased concentration of serum hyaluronate in psoriasis indicates involvement of dermal and synovial tissue in psoriasis, in addition to the epidermal changes.

Hyaluronan in joint disease

“…Also in patients with systemic sclerosis, which is a disease characterized by increased deposition of collagen and ground substance in the skin and internal organs, serum HYA levels are significantly elevated compared with controls [16,17]. In both psoriatic arthritis and reactive arthritis, the magnitude of the serum HYA levels depends on the degree of involvement of the peripheral joints [18]. In ankylosing spondylitis with an axial involvement and few peripheral joints affected, serum HYA levels remain normal.…”

Hyaluronan in skin

“…Patients with psoriasis have elevated levels of HYA in serum and in suction blisters raised on the lesions [13,20,21]. With the aid of HABP, the HYA has been localized especially to the dermal papillae and around appendages [2,22].…”

Regulation of hyaluronan synthase-2 expression in human intestinal mesenchymal cells: mechanisms of interleukin-1β-mediated induction

“…In macrophages and dendritic cells, intermediate-molecular weight hyaluronan can induce nitric oxide synthase (39). Furthermore, hyaluronan can induce dendritic cell apoptosis (19,20,35,38). Oligomeric hyaluronan (8 -16 disaccharides) induces angiogenesis in a chick cornea assay (58).…”

“…This includes rheumatoid arthritis, periodontitis, scleroderma, psoriasis, and inflammatory bowel disease (2,19,20,38,61). Various proinflammatory cytokines have been shown to influence hyaluronan expression in cells originating from connective tissue (29,34,53).…”