2019
DOI: 10.1002/mds.27928
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Abstract: Background A minimally invasive test for early detection and monitoring of Parkinson's disease (PD) is a highly unmet need for drug development and planning of patient care. Blood plasma represents an attractive source of biomarkers. MicroRNAs (miRNAs) are conserved noncoding RNA molecules that serve as posttranscriptional regulators of gene expression. As opposed to ubiquitously expressed miRNAs that control house‐keeping processes, brain‐enriched miRNAs regulate diverse aspects of neuron development and func… Show more

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Cited by 45 publications
(44 citation statements)
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References 107 publications
(179 reference statements)
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“…Here, we validated the ndings of our previous study [14], that had a speci c focus on brain-derived miRNAs, using an independent idiopathic PD cohort, and in depth analyzed current and previous data together to reveal not only a panel of deregulated miRNAs but also the upstream and downstream mediators of their effect.…”
Section: Introductionsupporting
confidence: 67%
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“…Here, we validated the ndings of our previous study [14], that had a speci c focus on brain-derived miRNAs, using an independent idiopathic PD cohort, and in depth analyzed current and previous data together to reveal not only a panel of deregulated miRNAs but also the upstream and downstream mediators of their effect.…”
Section: Introductionsupporting
confidence: 67%
“…The demographic and clinical characteristics of 92 healthy controls and 109 idiopathic PD (iPD) patients are summarized in Table 1. RT-qPCR was used to analyze the differential expression of 11 brain-enriched miRNAs [14] and the ubiquitous miR-22-3p that targets GBA mRNA [12] in the plasma of control and PD cohorts. Eight of these miRNAs have been previously identi ed as signi cantly deregulated in PD, while four approached statistical signi cance [14].…”
Section: Resultsmentioning
confidence: 99%
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“…Our results also highlighted a strong age related component of miRNA expression with two distinct waves of molecular onset. Ravanidis et al recently showed differentially expressed, brain-enriched miRNAs to have discriminatory power between iPD and genetic PD 42 . Comparably, we report a highly significant down-regulation of mitochondria, exosome, and brain expressed miRNAs over time in PD.…”
Section: Discussionmentioning
confidence: 99%