Circulating Antigen Antibody Complexes in Scabies

Neste, D. Van; Salmon, Jane E.

doi:10.1159/000250836

Cited by 24 publications

(5 citation statements)

References 8 publications

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“…We tried 10 detect circulating immune complcxes but no lgG complexes were found with thc C 10 -RlA. This is in ngreement with a prcvious study (9) in which such complexes were reported only in a treated (but not in an untreated) group of patients. In the present �tudy 5 patients had circulating lgM antibodies of RF type but there was no correlation to skin lF, or to serum lg and complement levels.…”

Section: Discussionsupporting

confidence: 73%

Immunoglobulin and complement deposits in the skin and circulating immune complexes in scabies

Salo,

Reunala,

Kalimo

et al. 1982

Acta Derm Venereol

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Sixteen patients with papulovesicular, 6 with nodular and one with a Norwegian scabies were studied. Direct immunofluorescence (IF) examination revealed C3 deposits in the skin lesions of 13 of the 18 patients. Among them were all 6 cases with nodular scabies. C3 was found mostly in dermal vessel walls and 3 of the patients also showed IgM and 2 IgA deposits at the same site. No circulating immune complexes were found, with a solid-phase C1q radioimmunoassay (RIA), but HSV- and RSV-RIA methods detected IgM antibodies of rheumatoid factor type in 5 of the 15 sera examined. These results suggest that local complement activation and perhaps also immune complex deposition may by important in the pathogenesis of the papular and nodular skin lesions of human scabies.

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Section: Discussionsupporting

confidence: 73%

Immunoglobulin and complement deposits in the skin and circulating immune complexes in scabies

Salo,

Reunala,

Kalimo

et al. 1982

Acta Derm Venereol

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“…Howev er, few controlled studies have investigated and thoroughly characterized this response for any host. Both immunized and naturally infested rabbits, pigs, and guinea pigs exhibit serum antibodies directed at S. scabiei antigens (12,15,104,118,121,122). antibodies to nine different antigens (12).…”

Section: Humoral Immune Responsementioning

confidence: 99%

Biology, Host Relations, and Epidemiology of Sarcoptes scabiei

Arlian¹

1989

Annu. Rev. Entomol.

207

140

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Scabies continues to be an important parasitic disease of humans, and other mammals. Suprisingly for a disease that has afflicted humans since antiquity, little is directly known about the basic biology of the parasite, the host-parasite interactions, the host immune response, and host susceptibility. Much more research in these areas is needed if we are to understand fully the occurrence, transmission, and epidemiology of both human and animal scabies.

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“…Type III reaction may also occur in scabies cases (23)(24)(25)(26). Vasculitis with fibiinoid degeneration of the vessel wall while a|3pareiitly uncommon in ordinay scabietie lesions, appears relatively usual in nodular lesions (2).…”

Section: Discussionmentioning

confidence: 99%

Scabietic nodules: a dermatopathologic and immunofluorescent study

1992

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Mites and their eggs were thought to be rarely found in nodular lesions of scabies. However, serial sections from 27 scabietic scrotal papules or nodules revealed mite parts in 22% (6/27). This supports the contention that scabietic nodules may result from persisting antigens of mite parts. In contrast to previous studies, vasculitis with fibrinoid degeneration was uncommon (3/27) in our series. This discrepancy may be due to the timing of the biopsies: 2 of 3 cases with vasculitis were associated with diffuse dense infiltration, and vasculitis may be a late event in the development of scabietic nodules. The specificity of immunoreactant deposits along the epidermodermal junction (EDJ) in scabies is controversial. In our study, direct immunofluorescence (DIF) was performed on 13 scabietic nodules. Four (31%) showed immunoreactants at the EDJ and two on blood vessels. Because of the relatively low positive rate, the low intensity of fluorescence, and 3 of 4 cases with positive immunoreactants having only a single class of immunoglobulin, the deposition may only be secondary to inflammation instead of a specific type II immunologic reaction to scabies.

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Circulating Antigen Antibody Complexes in Scabies

Abstract: Circulating immune complexes measured by the binding of Clq in 29 scabies patients and 52 control individuals have been found increased in the treated scabies patient.

Cited by 24 publications

References 8 publications

Immunoglobulin and complement deposits in the skin and circulating immune complexes in scabies

Immunoglobulin and complement deposits in the skin and circulating immune complexes in scabies

Biology, Host Relations, and Epidemiology of Sarcoptes scabiei

Scabietic nodules: a dermatopathologic and immunofluorescent study

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